Abemaciclib

目录号:S5716 批次号:S571603

打印

化学数据

化学结构式 别名 LY2835219 储存条件
(自收到货起)
3年 -20°C 粉状
化学式

C27H32F2N8

分子量 506.59 CAS号 1231929-97-7
Solubility (25°C)* 体外 Ethanol 10 mg/mL (19.73 mM)
DMSO 3 mg/mL (5.92 mM)
Water Insoluble
体内
(现配现用)
均匀悬浊液
CMC-NA
≥5mg/ml 以 1 mL 工作液为例,取 5 mg该产品加到 1 ml CMC-NA 溶液中,混合均匀,即可得工作液浓度为 5 mg/ml的均匀悬浊液。
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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生物活性

产品描述 Abemaciclib是一种对 CDK4/6 有选择性的细胞周期抑制剂,在无细胞试验中的IC50值分别为2 nM和10 nM。
靶点
CDK4 [1]
(Cell-free assay)
CDK6 [1]
(Cell-free assay)
2 nM 10 nM

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

Abemaciclib在文献中得到引用

Palmitoylation prevents B7-H4 lysosomal degradation sustaining tumor immune evasion [ Nat Commun, 2025, 16(1):4254] PubMed: 40341398
SLFN11-mediated ribosome biogenesis impairment induces TP53-independent apoptosis [ Mol Cell, 2025, S1097-2765(25)00042-5] PubMed: 39909041
PI3K/AKT signaling mediates stress-inducible amyloid formation through c-Myc [ Cell Rep, 2025, 44(5):115617] PubMed: 40272983
Efficacy of CDK4/6 Inhibition in colorectal cancer and the role of p16 expression in predicting drug resistance [ Cell Oncol (Dordr), 2025, 10.1007/s13402-025-01080-7] PubMed: 40522623
Intratumor heterogeneity in KRAS signaling shapes treatment resistance [ iScience, 2025, 28(2):111662] PubMed: 39898020
Investigation of ribociclib, abemaciclib and palbociclib resistance in ER+ breast cancer cells reveal potential therapeutic opportunities` [ Sci Rep, 2025, 15(1):28579] PubMed: 40764324
Abemaciclib induces G1 arrest and lysosomal dysfunction in canine melanoma cells: synergistic effects with fenbendazole [ Front Vet Sci, 2025, 12:1603686] PubMed: 40642276
FRA1 drives melanoma metastasis through an actionable transcriptional network [ bioRxiv, 2025, 2025.06.07.658418] PubMed: 40661443
Ginsenoside Rg5 enhances Abemaciclib sensitivity in ER+ breast cancer by modulating cell cycle proteins via transcriptional and post-translational levels [ J Ginseng Res, 2025, 49(5):594-603] PubMed: 40843016
Fibroblasts drive differential response in immunotherapy via IL-6 in bioengineered 3D cancer constructs [ bioRxiv, 2025, 2025.06.18.660473] PubMed: 40667289

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品,在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同,大多数建议储存在-20°C,抑制剂属于化学试剂,可在常温下运输储存两周左右。即使如此,我们保证产品的出货量将保持产品质量的条件下,一般都会放入冰袋。望阁下收到产品后,请按照产品数据表建议适当存储。

如果需要长期保存,请于零下二十度低温保存。禁止用于人体及治疗!

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