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别名 | N/A | 储存条件 (自收到货起) |
3年 -20°C 粉状 | |
化学式 | C30H30F2N6O3 |
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分子量 | 560.59 | CAS号 | 2296729-00-3 | |
Solubility (25°C)* | 体外 | DMSO | 100 mg/mL (178.38 mM) | |
Ethanol | 8 mg/mL (14.27 mM) | |||
Water | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
产品描述 | Sotorasib (AMG510) 是有效的KRAS G12C共价抑制剂,具有潜在的抗肿瘤活性。该AMG510是手性化合物。 | |
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体外研究 | AMG 510抑制SOS1催化的重组突变体KRAS (G12C/C118A)的核苷酸交换,但对单突变KRAS (C118A)影响甚微。AMG 510选择性地降低含KRAS p.G12C突变的细胞系生存活力,而对含其它KRAS突变的细胞系无影响[1]。 |
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体内研究 | 在临床前肿瘤模型中,AMG 510可快速地以不可逆方式结合KRAS (G12C),持久地抑制MAPK信号通路。对含KRAS(G12C)突变的小鼠肿瘤模型通过口服途径单次给药,AMG 510能够诱导肿瘤消退[2]。 |
Engineered a dual-targeting HA-TPP/A nanoparticle for combination therapy against KRAS-TP53 co-mutation in gastrointestinal cancers [ Bioact Mater, 2024, 32:277-291] | PubMed: 37876556 |
Targeting of vulnerabilities of drug-tolerant persisters identified through functional genetics delays tumor relapse [ Cell Rep Med, 2024, 5(3):101471] | PubMed: 38508142 |
AXL signal mediates adaptive resistance to KRAS G12C inhibitors in KRAS G12C-mutant tumor cells [ Cancer Lett, 2024, 587:216692] | PubMed: 38342232 |
Hedgehog signalling is involved in acquired resistance to KRASG12C inhibitors in lung cancer cells [ Cell Death Dis, 2024, 15(1):56] | PubMed: 38225225 |
Molecular Characterization of Acquired Resistance to KRASG12C-EGFR Inhibition in Colorectal Cancer [ Cancer Discov, 2023, 13(1):41-55] | PubMed: 36355783 |
LKB1-Dependent Regulation of TPI1 Creates a Divergent Metabolic Liability between Human and Mouse Lung Adenocarcinoma [ Cancer Discov, 2023, 13(4):1002-1025] | PubMed: 36715544 |
LKB1-Dependent Regulation of TPI1 Creates a Divergent Metabolic Liability between Human and Mouse Lung Adenocarcinoma [ Cancer Discov, 2023, 13(4):1002-1025] | PubMed: 36715544 |
Glycolysis regulates KRAS plasma membrane localization and function through defined glycosphingolipids [ Nat Commun, 2023, 14(1):465] | PubMed: 36709325 |
Mutant KRAS Drives Immune Evasion by Sensitizing Cytotoxic T-Cells to Activation-Induced Cell Death in Colorectal Cancer [ Adv Sci (Weinh), 2023, 10(6):e2203757] | PubMed: 36599679 |
Genotype-phenotype mapping of a patient-derived lung cancer organoid biobank identifies NKX2-1-defined Wnt dependency in lung adenocarcinoma [ Cell Rep, 2023, 42(3):112212] | PubMed: 36870059 |
特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品,在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同,大多数建议储存在-20°C,抑制剂属于化学试剂,可在常温下运输储存两周左右。即使如此,我们保证产品的出货量将保持产品质量的条件下,一般都会放入冰袋。望阁下收到产品后,请按照产品数据表建议适当存储。
如果需要长期保存,请于零下二十度低温保存。禁止用于人体及治疗!
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