Apatinib

目录号：S5248 批次号：S524801

化学数据

	别名	Rivoceranib, YN968D1	储存条件 (自收到货起)	3年 -20°C 粉状
	化学式	C₂₄H₂₃N₅O
	分子量	397.47	CAS号	811803-05-1
Solubility (25°C)*	体外	DMSO	79 mg/mL (198.75 mM)
		Ethanol	10 mg/mL (25.15 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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生物活性

产品描述

Apatinib (Rivoceranib, YN968D1) 是一种有效的VEGF信号通路的抑制剂，其对VEGFR-2、Ret、c-Kit和c-Src的IC50值分别为1 nM、13 nM、429 nM和530 nM。Apatinib可诱导自噬和凋亡。

靶点

VEGFR2 ^[1] (Cell-free assay)	RET ^[1] (Cell-free assay)
1 nM	13 nM

参考文献

[1] Tian S, et al. Cancer Sci. 2011, 102(7):1374-80.

Apatinib在文献中得到引用

Apatinib weakens proliferation, migration, invasion, and angiogenesis of thyroid cancer cells through downregulating pyruvate kinase M2 [ Sci Rep, 2024, 14(1):879]	PubMed: 38195651
N4-Acetylcytidine Drives Glycolysis Addiction in Gastric Cancer via NAT10/SEPT9/HIF-1α Positive Feedback Loop [ Adv Sci (Weinh), 2023, 10(23):e2300898]	PubMed: 37328448
HER4 and EGFR activate cell signaling in NRG1 fusion-driven cancers: implications for HER2/HER3-specific vs. pan-HER targeting strategies [ J Thorac Oncol, 2023, S1556-0864(23)00802-X]	PubMed: 37678511
Integrative analysis of multi-omics data reveals inhibition of RB1 signaling promotes apatinib resistance of hepatocellular carcinoma [ Int J Biol Sci, 2023, 19(14):4511-4524]	PubMed: 37781033
Dihydroartemisinin Potentiates VEGFR-TKIs Antitumorigenic Effect on Osteosarcoma by Regulating Loxl2/VEGFA Expression and Lipid Metabolism Pathway [ J Cancer, 2023, 14(5):809-820]	PubMed: 37056396
RECOVER identifies synergistic drug combinations in vitro through sequential model optimization [ Cell Rep Methods, 2023, 3(10):100599]	PubMed: 37797618
The interactions between integrin α5β1 of liver cancer cells and fibronectin of fibroblasts promote tumor growth and angiogenesis [ Int J Biol Sci, 2022, 18(13):5019-5037]	PubMed: 35982891
Apatinib enhances chemosensitivity of ABT-199 in diffuse large B-cell lymphoma [ Mol Oncol, 2022, 16(20):3735-3753]	PubMed: 36053810
Anti-Tumor Effect of Apatinib and Relevant Mechanisms in Liposarcoma [ Front Oncol, 2021, 11:739139]	PubMed: 34868934
TRIM21 improves apatinib treatment in gastric cancer through suppressing EZH1 stability [ Biochem Biophys Res Commun, 2021, 586:177-184]	PubMed: 34856418

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如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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