ATF4 Rabbit Recombinant mAb Datasheet

生物描述

特异性	ATF4 Rabbit Recombinant mAb detects endogenous level of total ATF4.
背景	Activating transcription factor 4 (ATF4), a member of the ATF/CREB transcription factor family, is an important factor that participates in several pathophysiological processes such as the stress response, bone resorption, medullary hematopoiesis and lens formation. It forms homodimers and heterodimers with other transcription factors, including some members of the AP-1 family. ATF4 acts as a transcription activator and inhibitor. Its activity is primarily regulated at the post-transcriptionally level, especially the translation of ATF4 mRNA. The protein degrades quickly, and its half-life is only 30-60 min.

特异性

ATF4 Rabbit Recombinant mAb detects endogenous level of total ATF4.

背景

Activating transcription factor 4 (ATF4), a member of the ATF/CREB transcription factor family, is an important factor that participates in several pathophysiological processes such as the stress response, bone resorption, medullary hematopoiesis and lens formation. It forms homodimers and heterodimers with other transcription factors, including some members of the AP-1 family. ATF4 acts as a transcription activator and inhibitor. Its activity is primarily regulated at the post-transcriptionally level, especially the translation of ATF4 mRNA. The protein degrades quickly, and its half-life is only 30-60 min.

使用信息

抗体应用

WB, IF,ELISA,ELISA

稀释比例

WB	IF
1:1000	1:50

反应性

Human Mouse Rat

MW (kDa)

50kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

[1] Zhang C, et al. Cell Mol Immunol. 2013, 10(1):84-94.

Application Data

WB

Validated by Selleck

IF

Validated by Selleck