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别名 | N/A | 储存条件 (自收到货起) |
3年 / -20°C / 粉状 1年 / -80°C / 溶于溶剂 |
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化学式 | C34H40N2O18 |
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分子量 | 764.68 | CAS号 | 126150-97-8 | |
Solubility (25°C)* | 体外 | DMSO | 20 mg/mL (26.15 mM) | |
Water | Insoluble | |||
Ethanol | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
产品描述 | BAPTA-AM 是选择透过性膜calcium螯合剂。 |
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体外研究 | BAPTA-AM,作为细胞内钙离子螯合剂,在小鼠皮质培养基中通过脂肪氧合酶介导的自由基诱导延迟坏死。[1] 在HEK 293细胞中,BAPTA-AM对hERG,hKv1.3 和 hKv1.5 通道表现出开放通道阻滞作用, IC50 为1.3,1.45 和 1.23 μM。[2] |
体内研究 | 在BDL大鼠体内,BAPTA-AM废除UDCA-和TUDCA诱导的Ca2+水平或Ca2+依赖性PKC-α磷酸化的增加,并抵消UDCA 和TUDCA对胆道迷走神经切断术诱发的伤害产生的细胞保护作用。[3] |
动物实验 | 动物模型 | BDL大鼠 |
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剂量 | ~6 毫克/千克 | |
给药处理 | 腹腔注射 |
, J Cell Mol Med, 2017, 21(7):1373-1387
数据来源于[Data independently produced by , , Acta Pharm Sin B, 2018, 8(6):909-918]
数据来源于[Data independently produced by , , CNS Neurosci Ther, 2017, 23(4):291-300]
数据来源于[Data independently produced by , , Exp Cell Res, 2017, 358(2):360-368]
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如果需要长期保存,请于零下二十度低温保存。禁止用于人体及治疗!
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