BCHE Rabbit Recombinant mAb Datasheet

生物描述

特异性	BCHE Rabbit Recombinant mAb detects endogenous level of total BCHE.
背景	Butyrylcholinesterase is a serine hydrolase related to acetylcholinesterase that catalyses the hydrolysis of esters of choline, including acetylcholine. Butyrylcholinesterase functions in neurotransmission to hydrolyze acetylcholine. Endogenous butyrylcholinesterase in human plasma, liver, lung, intestinal tract, and skin serves to detoxify poisons. By scavenging organophosphorus pesticides and nerve agents butyrylcholinesterase protects the neurotransmitter function of acetylcholinesterase, preventing respiratory failure and death. By inactivating cocaine, butyrylcholinesterase protects overstimulation by dopamine, thus preventing seizures, heart failure, and death. By inactivating succinylcholine and mivacurium, butyrylcholinesterase protects acetylcholine receptors, where blocking of neurotransmission paralyzes the breathing muscles. Butyrylcholinesterase acts as a backup for acetylcholinesterase by hydrolyzing acetylcholine that has diffused out of nerve synapse and also has a role in thermoregulation, and in fat utilization.

特异性

BCHE Rabbit Recombinant mAb detects endogenous level of total BCHE.

背景

Butyrylcholinesterase is a serine hydrolase related to acetylcholinesterase that catalyses the hydrolysis of esters of choline, including acetylcholine. Butyrylcholinesterase functions in neurotransmission to hydrolyze acetylcholine. Endogenous butyrylcholinesterase in human plasma, liver, lung, intestinal tract, and skin serves to detoxify poisons. By scavenging organophosphorus pesticides and nerve agents butyrylcholinesterase protects the neurotransmitter function of acetylcholinesterase, preventing respiratory failure and death. By inactivating cocaine, butyrylcholinesterase protects overstimulation by dopamine, thus preventing seizures, heart failure, and death. By inactivating succinylcholine and mivacurium, butyrylcholinesterase protects acetylcholine receptors, where blocking of neurotransmission paralyzes the breathing muscles. Butyrylcholinesterase acts as a backup for acetylcholinesterase by hydrolyzing acetylcholine that has diffused out of nerve synapse and also has a role in thermoregulation, and in fat utilization.

使用信息

抗体应用

WB,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human

MW (kDa)

90kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

Application Data

WB

Validated by Selleck