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目录号:A2006 批次号: A200603
Bevacizumab (anti-VEGF, Avastin) 是一种人源化的anti-VEGF单克隆抗体,是VEGF的抑制剂。可与所有人源VEGF-A亚型(和具有生物活性的蛋白水解片段)结合、中和。MW:149 KD。
CAS号 | 216974-75-3 |
---|---|
配制 | PBS buffer, pH 7.2 |
推荐同型对照 | Human IgG1 |
来源 | CHO cells |
储存条件 (自收到货起) |
Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles |
纯度 | 99.3% |
蛋白浓度 | 5mg/ml |
内毒素 | ≤1 EU/mg |
数据来源于[Data independently produced by , , Cancer Lett, 2018, 439:78-90]
VEGFA expression in the indicated cells treated with or without bevacizumab or transfected with VEGFA or shVEGFA.
Leukemic stem cells activate lineage inappropriate signalling pathways to promote their growth [ Nat Commun, 2024, 15(1):1359] | PubMed: 38355578 |
Interferon-regulatory factor-1 boosts bevacizumab cardiotoxicity by the vascular endothelial growth factor A/14-3-3γ axis [ ESC Heart Fail, 2024, 10.1002/ehf2.14640] | PubMed: 38234115 |
EDIL3 as an Angiogenic Target of Immune Exclusion Following Checkpoint Blockade [ Cancer Immunol Res, 2023, 11(11):1493-1507] | PubMed: 37728484 |
L1CAM promotes vasculogenic mimicry formation by miR-143-3p-induced expression of hexokinase 2 in glioma [ Mol Oncol, 2023, none] | PubMed: 36708044 |
In vitro vascularized immunocompetent patient-derived model to test cancer therapies [ iScience, 2023, 26(10):108094] | PubMed: 37860774 |
Development of an Anti-Idiotype Aptamer-Based Electrochemical Sensor for a Humanized Therapeutic Antibody Monitoring [ Int J Mol Sci, 2023, 24(6)5277] | PubMed: 36982354 |
Development of an Anti-Idiotype Aptamer-Based Electrochemical Sensor for a Humanized Therapeutic Antibody Monitoring [ Int J Mol Sci, 2023, 24(6)5277] | PubMed: 36982354 |
Subcutaneous transplantation of human embryonic stem cells-derived pituitary organoids [ Front Endocrinol (Lausanne), 2023, 14:1130465] | PubMed: 36936140 |
Angiopoietin-2 and the Vascular Endothelial Growth Factor Promote Migration and Invasion in Hepatocellular Carcinoma- and Intrahepatic Cholangiocarcinoma-Derived Spheroids [ Biomedicines, 2023, 12(1)87] | PubMed: 38255193 |
Immune suppressive signaling regulated by latent transforming growth factor beta binding protein 1 promotes metastasis in cervical cancer [ Braz J Med Biol Res, 2023, 55:e12206] | PubMed: 36629522 |
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