Blasticidin S HCl

目录号：S7419 批次号：S741904

化学数据

	别名	N/A	储存条件 (自收到货起)	3年 / -20°C / 粉状 1年 / -80°C / 溶于溶剂
	化学式	C₁₇H₂₇ClN₈O₅
	分子量	458.9	CAS号	3513-03-9
Solubility (25°C)*	体外	Water	91 mg/mL (198.3 mM)
		DMSO	Insoluble
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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生物活性

产品描述

Blasticidin S HCl 是一种从 Stretomyces girseochromogenes 中分离出来的核苷antibiotic。它通过阻断释放因子诱导的肽基-tRNA 水解来发挥作用，并抑制肽键形成。它用于选择携带bsr或BSD抗性基因的转染细胞。

靶点

protein synthesis ^[1]

DNA synthesis ^[1]

体外研究

Blasticidin S抑制蛋白质合成，通过作用于多肽从肽基- sRNA转移到氨酰基- sRNA的步骤发挥作用。^[1]

Blasticidin S也会显著抑制DNA合成，而独立于其对蛋白质合成的作用。^[2]

Blasticidin S能够比G418更快的杀死细胞，这对于哺乳动物细胞，耐blasticidin S基因(bsr)成为一种选择性标记。^[3]

此外，Blasticidin S也能有效结合Cu(II)离子，并防止DNA被金属诱导的损伤破坏。^[4]

参考文献

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Blasticidin S HCl在文献中得到引用

STK19 is a transcription-coupled repair factor that participates in UVSSA ubiquitination and TFIIH loading [ Nucleic Acids Res, 2024, gkae787]	PubMed: 39353615
Targeting the HSP47-collagen axis inhibits brain metastasis by reversing M2 microglial polarization and restoring anti-tumor immunity [ Cell Rep Med, 2024, 5(5):101533]	PubMed: 38744278
Targeting the HSP47-collagen axis inhibits brain metastasis by reversing M2 microglial polarization and restoring anti-tumor immunity [ Cell Rep Med, 2024, 5(5):101533]	PubMed: 38744278
BMP suppresses Wnt signaling via the Bcl11b-regulated NuRD complex to maintain intestinal stem cells [ EMBO J, 2024, ]	PubMed: 39433900
YEATS domain-containing protein GAS41 regulates nuclear shape by working in concert with BRD2 and the mediator complex in colorectal cancer [ Pharmacol Res, 2024, 206:107283]	PubMed: 38964523
Mitochondrial transplantation rescues Ca2+ homeostasis imbalance and myocardial hypertrophy in SLC25A3-related hypertrophic cardiomyopathy [ Cell Rep, 2024, 43(12):115065]	PubMed: 39671292
Chicoric Acid Ameliorated Beta-Amyloid Pathology and Enhanced Expression of Synaptic-Function-Related Markers via L1CAM in Alzheimer's Disease Models [ Int J Mol Sci, 2024, 25(6)3408]	PubMed: 38542381
Expression levels and stoichiometry of Hnf1β, Emx2, Pax8 and Hnf4 influence direct reprogramming of induced renal tubular epithelial cells [ Cell Regen, 2024, 13(1):19]	PubMed: 39347883
Repression of LSD1 potentiates homologous recombination-proficient ovarian cancer to PARP inhibitors through down-regulation of BRCA1/2 and RAD51 [ Nat Commun, 2023, 10.1038/s41467-023-42850-x]	PubMed: 37973845
Genetically encoded photocatalytic protein labeling enables spatially-resolved profiling of intracellular proteome [ Nat Commun, 2023, 14(1):2978]	PubMed: 37221179

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如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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