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别名 | N/A | 储存条件 (自收到货起) |
3年 / -20°C / 粉状 1年 / -80°C / 溶于溶剂 |
化学式 | C24H24Cl2N4O4 |
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分子量 | 503.38 | CAS号 | 1707289-21-1 | |
Solubility (25°C)* | 体外 | DMSO | 100 mg/mL (198.65 mM) | |
Ethanol | 2 mg/mL (3.97 mM) | |||
Water | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
产品描述 | Fisogatinib (BLU-554)是一种有效的、高度选择性的、具有口服活性的FGFR4抑制剂,IC50为5 nM。对FGFR1-3的IC50范围为624-2203 nM。 | ||
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体外研究 | BLU-554与FGFR4相互作用,对FGFR4的抑制具有高效力和选择性[1]。 |
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体内研究 | BLU-554在肿瘤模型中具有良好的耐受性。在肝癌模型中诱导肿瘤消退[1]。 |
Molecular Interaction of Soluble Klotho with FGF23 in the Pathobiology of Aortic Valve Lesions Induced by Chronic Kidney Disease [ Int J Biol Sci, 2024, 20(9):3412-3425] | PubMed: 38993571 |
Fibroblast Growth Factor Receptor 4 Promotes Triple-Negative Breast Cancer Progression via Regulating Fatty Acid Metabolism Through the AKT/RYR2 Signaling [ Cancer Med, 2024, 13(23):e70439] | PubMed: 39658878 |
FGF19-Induced Inflammatory CAF Promoted Neutrophil Extracellular Trap Formation in the Liver Metastasis of Colorectal Cancer [ Adv Sci (Weinh), 2023, 10(24):e2302613] | PubMed: 37345586 |
Fibroblast growth factor receptor 4 promotes glioblastoma progression: a central role of integrin-mediated cell invasiveness [ Acta Neuropathol Commun, 2022, 10(1):65] | PubMed: 35484633 |
BLU-554, A selective inhibitor of FGFR4, exhibits anti-tumour activity against gastric cancer in vitro [ Biochem Biophys Res Commun, 2022, 595:22-27] | PubMed: 35093636 |
EGFR activation limits the response of liver cancer to lenvatinib [ Nature, 2021, 595(7869):730-734] | PubMed: 34290403 |
Activation of receptor tyrosine kinases mediates acquired resistance to MEK inhibition in malignant peripheral nerve sheath tumors [ Cancer Res, 2020, canres.1992.2020] | PubMed: 33203698 |
Chemosensitivity of Patient-Derived Cancer Stem Cells Identifies Colorectal Cancer Patients with Potential Benefit from FGFR Inhibitor Therapy [ Cancers (Basel), 2020, 12(8):E2010] | PubMed: 32708005 |
Protein tyrosine kinase 2: a novel therapeutic target to overcome acquired EGFR-TKI resistance in non-small cell lung cancer [ Respir Res, 2019, 20(1-:270] | PubMed: 31791326 |
特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品,在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同,大多数建议储存在-20°C,抑制剂属于化学试剂,可在常温下运输储存两周左右。即使如此,我们保证产品的出货量将保持产品质量的条件下,一般都会放入冰袋。望阁下收到产品后,请按照产品数据表建议适当存储。
如果需要长期保存,请于零下二十度低温保存。禁止用于人体及治疗!
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