Bmi1 Rabbit Recombinant mAb

生物描述

特异性

Bmi1 Rabbit Recombinant mAb detects endogenous level of total Bmi1.

背景

Bmi-1 is a member of the Polycomb repressor complex 1 that mediates gene silencing by regulating chromatin structure and is indispensable for self-renewal of both normal and cancer stem cells. Bmi-1 has been implicated in a number of biological pathways including development, cell cycle, DNA damage response (DDR), senescence, stem cell, self-renewal and cancer. Bmi-1 has a number of transcriptional and post-transcriptional regulators. Myc-N, c-Myc, Sp1, Twist1, FOXM1, E2F-1 and SALL4 have been shown to positively regulate Bmi-1 expression while KLF4, Mel-18 and histone deacetylase inhibitors (HDACi) have been shown to suppress expression at the transcriptional level.

使用信息

抗体应用	WB, IF,ELISA,ELISA
稀释比例	WB IF 1:1000 1:50
反应性	Human Rat
MW (kDa)	40kDa
抗体类型	Rabbit
储存液配方	10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
储存条件 (自收到货起)	Store at –20°C.

文献参考

[1] Bhattacharya R, et al. Genes Dis. 2015, 2(3):225-239. [2] Resham Bhattacharya, et al. Genes Dis. 2015, 2(3): 225–239.

Application Data

WB

IF