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别名 | DUP785, NSC 368390 | 储存条件 (自收到货起) |
3年 -20°C 粉状 | ||||
化学式 | C23H15F2NO2 |
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分子量 | 375.37 | CAS号 | 96187-53-0 | ||||
Solubility (25°C)* | 体外 | DMSO | 38 mg/mL (101.23 mM) | ||||
Water | Insoluble | ||||||
Ethanol | Insoluble | ||||||
体内(现配现用) |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
产品描述 | Brequinar是二氢乳清酸脱氢酶DHODH抑制剂,在体外IC50约为20 nM。 | ||
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靶点 |
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SIRT4 loss reprograms intestinal nucleotide metabolism to support proliferation following perturbation of homeostasis [ Cell Rep, 2024, 43(4):113975] | PubMed: 38507411 |
Gut microbiota-mediated nucleotide synthesis attenuates the response to neoadjuvant chemoradiotherapy in rectal cancer [ Cancer Cell, 2023, 41(1):124-138.e6] | PubMed: 36563680 |
Synchronous Disintegration of Ferroptosis Defense Axis via Engineered Exosome-Conjugated Magnetic Nanoparticles for Glioblastoma Therapy [ Adv Sci (Weinh), 2022, e2105451] | PubMed: 35508804 |
EGFR-phosphorylated GDH1 harmonizes with RSK2 to drive CREB activation and tumor metastasis in EGFR-activated lung cancer [ Cell Rep, 2022, 41(11):111827] | PubMed: 36516759 |
Brequinar and dipyridamole in combination exhibits synergistic antiviral activity against SARS-CoV-2 in vitro: Rationale for a host-acting antiviral treatment strategy for COVID-19 [ Antiviral Res, 2022, 206:105403] | PubMed: 36041646 |
Inhibitors of dihydroorotate dehydrogenase cooperate with molnupiravir and N4-hydroxycytidine to suppress SARS-CoV-2 replication [ iScience, 2022, 25(5):104293] | PubMed: 35492218 |
Metabolic inhibitor screening identifies dihydrofolate reductase as an inducer of the tumor immune escape mediator CD24 [ Immunomedicine, 2022, 2(2)e1041] | PubMed: 36816458 |
N4-hydroxycytidine and inhibitors of dihydroorotate dehydrogenase synergistically suppress SARS-CoV-2 replication [ bioRxiv, 2021, 10.1101/2021.06.28.450163] | PubMed: N/A |
特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品,在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同,大多数建议储存在-20°C,抑制剂属于化学试剂,可在常温下运输储存两周左右。即使如此,我们保证产品的出货量将保持产品质量的条件下,一般都会放入冰袋。望阁下收到产品后,请按照产品数据表建议适当存储。
如果需要长期保存,请于零下二十度低温保存。禁止用于人体及治疗!
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