BSO

目录号:S9728 批次号:S972802

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化学数据

化学结构式 别名 L-Buthionine sulfoximine, l-BSO 储存条件
(自收到货起)
3年 -20°C 粉状
化学式

C8H18N2O3S

分子量 222.31 CAS号 83730-53-4
Solubility (25°C)* 体外 Water 44 mg/mL (197.92 mM)
DMSO Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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生物活性

产品描述 BSO是一种有效的、可细胞渗透的,作用快的 g-glutamylcysteine synthetase (γ-glutamylcysteine synthetase, γ-GCS) 的不可逆抑制剂并可耗尽细胞内的谷胱甘肽水平。BSO 在黑色素瘤、乳腺癌和卵巢癌标本上的IC50值分别为1.9 μM、8.6 μM 和 29 μM。

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

BSO在文献中得到引用

SPTBN2 suppresses ferroptosis in NSCLC cells by facilitating SLC7A11 membrane trafficking and localization [ Redox Biol, 2024, 70:103039] PubMed: 38241838
A mycobacterial effector promotes ferroptosis-dependent pathogenicity and dissemination [ Nat Commun, 2023, 14(1):1430] PubMed: 36932056
Preclinical investigations of the efficacy of the glutaminase inhibitor CB-839 alone and in combinations in chronic lymphocytic leukemia [ Front Oncol, 2023, 13:1161254] PubMed: 37228498
ATF4 protects against sorafenib-induced cardiotoxicity by suppressing ferroptosis [ Biomed Pharmacother, 2022, 153:113280] PubMed: 35724508
Intratarget Microdosing for Deep Phenotyping of Multiple Drug Effects in the Live Brain [ Front Bioeng Biotechnol, 2022, 10:855755] PubMed: 35372313
High-throughput in situ perturbation of metabolite levels in the tumor micro-environment reveals favorable metabolic condition for increased fitness of infiltrated T-cells [ Front Cell Dev Biol, 2022, 10:1032360] PubMed: 36619865
Cystine Induced-mTORC2 Activation through Promoting Sin1 Phosphorylation to Suppress Cancer Cell Ferroptosis [ Mol Nutr Food Res, 2022, e2200186] PubMed: 36189894
CDC27-ODC1 Axis Promotes Metastasis, Accelerates Ferroptosis and Predicts Poor Prognosis in Neuroblastoma [ Front Oncol, 2022, 12:774458] PubMed: 35242701
Antioxidant glutathione inhibits inflammation in synovial fibroblasts via PTEN/PI3K/AKT pathway: An in vitro study [ Arch Rheumatol, 2022, 37(2):212-222] PubMed: 36017213
PARP inhibition promotes ferroptosis via repressing SLC7A11 and synergizes with ferroptosis inducers in BRCA-proficient ovarian cancer [ Redox Biol, 2021, S2213-2317(21)00076-8] PubMed: 33722571

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品,在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同,大多数建议储存在-20°C,抑制剂属于化学试剂,可在常温下运输储存两周左右。即使如此,我们保证产品的出货量将保持产品质量的条件下,一般都会放入冰袋。望阁下收到产品后,请按照产品数据表建议适当存储。

如果需要长期保存,请于零下二十度低温保存。禁止用于人体及治疗!

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