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别名 | L-Buthionine sulfoximine, l-BSO | 储存条件 (自收到货起) |
3年 -20°C 粉状 |
化学式 | C8H18N2O3S |
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分子量 | 222.31 | CAS号 | 83730-53-4 | |
Solubility (25°C)* | 体外 | Water | 44 mg/mL (197.92 mM) | |
DMSO | Insoluble | |||
Ethanol | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
产品描述 | BSO是一种有效的、可细胞渗透的,作用快的 g-glutamylcysteine synthetase (γ-glutamylcysteine synthetase, γ-GCS) 的不可逆抑制剂并可耗尽细胞内的谷胱甘肽水平。BSO 在黑色素瘤、乳腺癌和卵巢癌标本上的IC50值分别为1.9 μM、8.6 μM 和 29 μM。 |
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SPTBN2 suppresses ferroptosis in NSCLC cells by facilitating SLC7A11 membrane trafficking and localization [ Redox Biol, 2024, 70:103039] | PubMed: 38241838 |
Macroautophagy/autophagy promotes resistance to KRASG12D-targeted therapy through glutathione synthesis [ Cancer Lett, 2024, 604:217258] | PubMed: 39276914 |
Caspase-2 protects against ferroptotic cell death [ Cell Death Dis, 2024, 15(3):182] | PubMed: 38429264 |
A mycobacterial effector promotes ferroptosis-dependent pathogenicity and dissemination [ Nat Commun, 2023, 14(1):1430] | PubMed: 36932056 |
Preclinical investigations of the efficacy of the glutaminase inhibitor CB-839 alone and in combinations in chronic lymphocytic leukemia [ Front Oncol, 2023, 13:1161254] | PubMed: 37228498 |
ATF4 protects against sorafenib-induced cardiotoxicity by suppressing ferroptosis [ Biomed Pharmacother, 2022, 153:113280] | PubMed: 35724508 |
Intratarget Microdosing for Deep Phenotyping of Multiple Drug Effects in the Live Brain [ Front Bioeng Biotechnol, 2022, 10:855755] | PubMed: 35372313 |
High-throughput in situ perturbation of metabolite levels in the tumor micro-environment reveals favorable metabolic condition for increased fitness of infiltrated T-cells [ Front Cell Dev Biol, 2022, 10:1032360] | PubMed: 36619865 |
Cystine Induced-mTORC2 Activation through Promoting Sin1 Phosphorylation to Suppress Cancer Cell Ferroptosis [ Mol Nutr Food Res, 2022, e2200186] | PubMed: 36189894 |
CDC27-ODC1 Axis Promotes Metastasis, Accelerates Ferroptosis and Predicts Poor Prognosis in Neuroblastoma [ Front Oncol, 2022, 12:774458] | PubMed: 35242701 |
特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品,在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同,大多数建议储存在-20°C,抑制剂属于化学试剂,可在常温下运输储存两周左右。即使如此,我们保证产品的出货量将保持产品质量的条件下,一般都会放入冰袋。望阁下收到产品后,请按照产品数据表建议适当存储。
如果需要长期保存,请于零下二十度低温保存。禁止用于人体及治疗!
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