Caldesmon Rabbit Recombinant mAb

生物描述

特异性

Caldesmon Rabbit Recombinant mAb detects endogenous level of total Caldesmon.

背景

The protein caldesmon, originally isolated from smooth muscle tissue where it is the most abundant calmodulin-binding protein, has since been shown to have a wide distribution in actin- and myosin- containing cells where it is localized in sub-cellular structures concerned with motility, shape changes and exo- or endo-cytosis. Caldesmon is believed to be an actin- regulatory protein, and binds with high affinity to actin or actin-tropomyosin. Caldesmon inhibits the actin-activated myosin ATPase by blocking the interaction of actin and myosin and/or inhibiting a kinetic step of the actomyosin ATPase cycle. Inhibition of contraction by caldesmon can be released by binding of caldesmon to Ca2+/calmodulin and/or post-translational phosphorylation.

使用信息

抗体应用	WB, IHC,ELISA,ELISA
稀释比例	WB IHC 1:1000 1:50
反应性	Human Mouse Rat
MW (kDa)	70kDa
抗体类型	Rabbit
储存液配方	10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
储存条件 (自收到货起)	Store at –20°C.

文献参考

[1] Pritchard K, et al. Cell Calcium. 1986, 7(5-6):309-27. [2] Eves R, et al. J Cell Sci. 2006, 119(Pt 9):1691-702.

Application Data

WB

IHC