Capsaicin(Vanilloid)

目录号：S1990 批次号：S199003

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化学数据

化学结构式 别名 储存条件
(自收到货起)		 3年 / -20°C / 粉状
1年 / -80°C / 溶于溶剂
化学式

C18H27NO3
分子量 305.41 CAS号 404-86-4
Solubility (25°C)* 体外 DMSO 54 mg/mL (176.81 mM)
Ethanol 54 mg/mL (176.81 mM)
Water Insoluble
体内（现配现用）
澄清溶液
5%DMSO Corn oil
2.7mg/ml (8.84mM) 以 1 mL 工作液为例，取50μL54mg/ml的澄清DMSO储备液加到950μL玉米油中，混合均匀。工作液请现配现用！
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

生物活性

产品描述 Capsaicin(Vanilloid)是辣椒属红辣椒的活性成分。Capsaicin是一种TRPV1激动剂，在HEK293细胞中的EC50为0.29μM。Capsaicin(Vanilloid)是辣椒素和二氢辣椒素的混合物。

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

Capsaicin(Vanilloid)在文献中得到引用

Phytoformulation with hydroxycitric acid and capsaicin protects against high-fat-diet-induced obesity cardiomyopathy by reducing cardiac lipid deposition and ameliorating inflammation and apoptosis in the heart [ J Tradit Complement Med, 2024, 14(2):162-172] PubMed: 38481548
Effects of Oncolytic Vaccinia Viruses Harboring Different Marine Lectins on Hepatocellular Carcinoma Cells [ Int J Mol Sci, 2023, 24(4)3823] PubMed: 36835232
Interaction between TRPML1 and p62 in Regulating Autophagosome-Lysosome Fusion and Impeding Neuroaxonal Dystrophy in Alzheimer's Disease [ Oxid Med Cell Longev, 2022, 2022:8096009] PubMed: 35116093
Oncolytic Vaccinia Virus Harboring Aphrocallistes vastus Lectin Inhibits the Growth of Hepatocellular Carcinoma Cells [ Mar Drugs, 2022, 20(6)378] PubMed: 35736181
Electroacupuncture Pretreatment Attenuates Cerebral Ischemia-Reperfusion Injury in Rats Through Transient Receptor Potential Vanilloid 1-Mediated Anti-apoptosis via Inhibiting NF-κB Signaling Pathway [ Neuroscience, 2021, S0306-4522(21)00641-2] PubMed: 34929338
Paeoniflorin relieves LPS-induced inflammatory pain in mice by inhibiting NLRP3 inflammasome activation via transient receptor potential vanilloid 1. [ J Leukoc Biol, 2020, 10.1002/JLB.3MA0220-355R] PubMed: 32083340
Electroacupuncture Pretreatment Elicits Neuroprotection Against Cerebral Ischemia-Reperfusion Injury in Rats Associated with Transient Receptor Potential Vanilloid 1-Mediated Anti-Oxidant Stress and Anti-Inflammation [ Inflammation, 2019, 10.1007/s10753-019-01040-y] PubMed: 31190106
Capsaicin enhances the antitumor activity of sorafenib in hepatocellular carcinoma cells and mouse xenograft tumors through increased ERK signaling [ Acta Pharmacol Sin, 2018, 39(3):438-448] PubMed: 29188798
Capsaicin and sorafenib combination treatment exerts synergistic anti‑hepatocellular carcinoma activity by suppressing EGFR and PI3K/Akt/mTOR signaling [ Oncol Rep, 2018, 40(6):3235-3248] PubMed: 30272354
Nerve growth factor rescues diabetic mice heart after ischemia/reperfusion injury via up-regulation of the TRPV1 receptor. [ J Diabetes Complications, 2015, 29(3):323-8] PubMed: 25650182

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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