Catenin gamma Rabbit Recombinant mAb

生物描述

特异性

Catenin gamma Rabbit Recombinant mAb detects endogenous level of total catenin gamma.

背景

Beta-catenin is an essential element for the transcriptional activation of target genes in the Wnt signaling cascade and is also a cell adhesion molecule that couples with cadherins. Plakoglobin (gamma-catenin) is a closely related homologue of beta-catenin. γ-Catenin is a major protein in cell-cell adhesion at the desmosomes, where it also links transmembrane cadherins (desmogleins and desmocollins) to intermediate filaments of the actin cytoskeleton. γ-Catenin is found in the armadillo family of proteins along with β-catenin, shares nearly an 80% homology to β-catenin, and has a nearly identical interaction with E-cadherin. Plakoglobin (gamma-catenin) can activate the Wnt signaling cascade directly without interaction of beta-catenin, and that plakoglobin has multiple functions as a transcriptional activator and a cell adhesion molecule like beta-catenin.

使用信息

抗体应用	WB, IHC,ELISA,ELISA
稀释比例	WB IHC 1:1000 1:50
反应性	Human Mouse Rat
MW (kDa)	82kDa
抗体类型	Rabbit
储存液配方	10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
储存条件 (自收到货起)	Store at –20°C.

文献参考

[1] Maeda O, et al. Oncogene. 2004, 23(4):964-72. [2] Emily Diane Wickline, et al. Neoplasia. 2013, 15(4):421-34.

Application Data

WB

IHC