CCR8 Rabbit Recombinant mAb

生物描述

特异性

CCR8 Rabbit Recombinant mAb detects endogenous level of total CCR8.

背景

CCR8 is a T cell specific G-protein-coupled, 7-transmembrane receptor. Human CCR8 is expressed only in lymphoid organs and in particular in the thymus. Mouse CCR8 is also expressed mainly in the thymus. CCR8 is a CCL18 receptor. CCL18 bound with high affinity to CCR8 and induced its internalization. Human CCL1, the known endogenous CCR8 ligand, and CCL18 competed for binding to CCR8-transfected cells. CCR8 was shown to function as a HIV-1 coreceptor in primary human thymocytes for several HIV-1 strains. vMIP-1 and CCL1 are able to trigger a CCR8-mediated rescue from dex-induced apoptosis by an extracellular-regulated kinase (ERK)-dependent mechanism .

使用信息

抗体应用	WB, IF,ELISA,ELISA
稀释比例	WB IF 1:1000 1:50
反应性	Human Mouse Rat
MW (kDa)	41kDa
抗体类型	Rabbit
储存液配方	10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
储存条件 (自收到货起)	Store at –20°C.

文献参考

[1] Alessandra Zingoni, et al. The Journal of Immunology. 1998, 161:547-551. [2] Sabina A Islam, et al. J Exp Med. 2013, 210(10): 1889-1898. [3] Spinetti G, et al. J Leukoc Biol. 2003, 73(1):201-7.

Application Data

WB

IF