Datasheet

生物描述

特异性	CD27 Rabbit Recombinant mAb detects endogenous levels of total CD27
背景	CD27, a tumor necrosis factor receptor (TNFR)-associated factor-binding member of the TNFR family, regulates cellular activity in subsets of T, B, and natural killer cells as well as hematopoietic progenitor cells. CD27 is expressed as a disulphide-linked dimer and upon interaction with its unique ligand CD70 a truncated form of CD27 is released, most probably by a membrane-linked protease. Increase in soluble CD27 has been documented in situations of immune activation such as in autoimmune disease and during viral infection. CD70, the only CD27 ligand that has been identified, is a membrane expressed homotrimeric type II membrane molecule.

特异性

CD27 Rabbit Recombinant mAb detects endogenous levels of total CD27

背景

CD27, a tumor necrosis factor receptor (TNFR)-associated factor-binding member of the TNFR family, regulates cellular activity in subsets of T, B, and natural killer cells as well as hematopoietic progenitor cells. CD27 is expressed as a disulphide-linked dimer and upon interaction with its unique ligand CD70 a truncated form of CD27 is released, most probably by a membrane-linked protease. Increase in soluble CD27 has been documented in situations of immune activation such as in autoimmune disease and during viral infection. CD70, the only CD27 ligand that has been identified, is a membrane expressed homotrimeric type II membrane molecule.

使用信息

抗体应用

wb,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human Rat

MW (kDa)

55kDa

抗体类型

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

[1] Nolte MA, et al. Drug Dev Ind Pharm. 2009;229(1):216-31.

Application Data

WB

Validated by Selleck