Datasheet

生物描述

特异性	CD39 Rabbit Recombinant mAb detects endogenous levels of total CD39.
背景	CD39 is an integral membrane protein that phosphohydrolyzes ATP, and less efficiently ADP, in a Ca2+- and Mg2+-dependent fashion, to yield AMP. CD39 becomes catalytically active upon its localization on the cell surface, and its glycosylation is crucial for correct protein folding, membrane targeting, and enzyme activity. CD39 is constitutively expressed in spleen, thymus, lung, and placenta, and in these organs it is associated primarily with endothelial cells and immune cell populations, such as B cells, natural killer (NK) cells, dendritic cells, Langerhans cells, monocytes, macrophages, mesangial cells, neutrophils, and regulatory T cells (Tregs). In addition, the expression of CD39 is increased in several solid tumors (colorectal cancer, head and neck cancer, pancreatic cancer) as well as in chronic lymphocytic leukemia.

特异性

CD39 Rabbit Recombinant mAb detects endogenous levels of total CD39.

背景

CD39 is an integral membrane protein that phosphohydrolyzes ATP, and less efficiently ADP, in a Ca2+- and Mg2+-dependent fashion, to yield AMP. CD39 becomes catalytically active upon its localization on the cell surface, and its glycosylation is crucial for correct protein folding, membrane targeting, and enzyme activity. CD39 is constitutively expressed in spleen, thymus, lung, and placenta, and in these organs it is associated primarily with endothelial cells and immune cell populations, such as B cells, natural killer (NK) cells, dendritic cells, Langerhans cells, monocytes, macrophages, mesangial cells, neutrophils, and regulatory T cells (Tregs). In addition, the expression of CD39 is increased in several solid tumors (colorectal cancer, head and neck cancer, pancreatic cancer) as well as in chronic lymphocytic leukemia.

使用信息

抗体应用

wb,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human Mouse Rat

MW (kDa)

70kDa

抗体类型

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

Application Data

WB

Validated by Selleck