CD45 Rabbit Recombinant mAb Datasheet

生物描述

特异性	CD45 Rabbit Recombinant mAb detects endogenous level of CD45.
背景	CD45, the first and prototypic receptor-like protein tyrosine phosphatase, is expressed on all nucleated hematopoietic cells and plays a central role in this process. CD45 plays enssential roles in antigen receptor signal transduction and lymphocyte development. CD45 also modulates signals emanating from integrin and cytokine receptors. In addition to T cells and B cells, CD45 also functions in other cell types: CD45 is essential for histamine degranulation after immunoglobulin E (IgE) receptor cross-linking in mast cells, CD45 may also modulate chemokine-induced signaling in neutrophils and plays a pivotal role in signal transduction in leukocytes.

特异性

CD45 Rabbit Recombinant mAb detects endogenous level of CD45.

背景

CD45, the first and prototypic receptor-like protein tyrosine phosphatase, is expressed on all nucleated hematopoietic cells and plays a central role in this process. CD45 plays enssential roles in antigen receptor signal transduction and lymphocyte development. CD45 also modulates signals emanating from integrin and cytokine receptors. In addition to T cells and B cells, CD45 also functions in other cell types: CD45 is essential for histamine degranulation after immunoglobulin E (IgE) receptor cross-linking in mast cells, CD45 may also modulate chemokine-induced signaling in neutrophils and plays a pivotal role in signal transduction in leukocytes.

使用信息

抗体应用

WB, IHC,ELISA,ELISA

稀释比例

WB	IHC
1:1000	1:50

反应性

Human

MW (kDa)

150kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

[1] Hermiston ML, et al. Annu Rev Immunol. 2003, 21:107-37.

Application Data

IHC

Validated by Selleck