生物描述

特异性

CD7 Rabbit Recombinant mAb detects endogenous levels of total CD7

背景

CD7 is a transmembrane glycoprotein which appears early in T cell ontogeny and is expressed by most T cells in the periphery. A subset of CD4 T cells which do not express CD7 has previously been described, but the role of CD7 in CD8 T cell differentiation and maturation is unknown. Although the ligand is yet not identified, CD7 has been recognized as a costimulatory molecule. CD7 activates phosphatidylinositol 3-kinase which is involved in CD7-mediated regulation of integrin adhesiveness. Furthermore, it has been reported that the β-galactoside-binding lectin galectin-1 binds CD7, leading to induction of apoptosis of thymocytes and T cells, with implications for certain autoimmune diseases and T cell lymphomas.

使用信息

抗体应用	WB, IHC,ELISA,ELISA
稀释比例	WB IHC 1:1000 1:50
反应性	Human
MW (kDa)	37kDa
抗体类型
储存液配方	10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
储存条件 (自收到货起)	Store at –20°C.

文献参考

[1] Aandahl EM, et al. J Immunol. 2003,1;170(5):2349-55.

Application Data

WB

IHC