全国免费电话:400-668-6834 -- 仅限中国地区 -- |
在线订购:QQ: 4006686834 电话订购:021-68591985 邮件订购:info@selleck.cn 我们也提供销售人员上门服务 |
技术支持电话:400-168-6834 我们将于一个工作日与您联系 |
目录号:A5843
特异性 | CD89 Rabbit Recombinant mAb detects endogenous levels of total CD89 |
---|---|
背景 | CD89 (FcαRI) is the human myeloid IgA Fc receptor expressed on cells, such as neutrophils, eosinophils and monocytes/macrophages. It is a transmembrane glycoprotein that binds both subclasses of IgA in all its molecular forms (i.e. monomeric, dimeric and secretory IgA) via a region of its membrane-distal EC1 domain. Various cytokines and other factors can modulate surface expression of CD89. CD89 is up-regulated on neutrophils in response to formyl-methionyl-leucyl-phenylalanine (FMLP), interleukin 8 (IL-8), and tumor necrosis factor α (TNF-α). The CD89 levels can also be modulated by Ca2+-dependent signaling processes in both neutrophils and eosinophils. The expression of CD89 on monocytes and monocyte-like cell lines can be up-regulated by Calcitriol, lipopolysaccharide (LPS), TNF-α, granulocyte-macrophage colony stimulating factor (GM-CSF) and IL-1β, and downregulated by suramin and transforming growth factor-β (TGF-β). CD89 appears to play an important role in immune defense by linking the humoral IgA response to powerful cellular effector mechanisms. |
抗体应用 | WB, IHC,ELISA,ELISA | ||||
---|---|---|---|---|---|
稀释比例 |
|
||||
反应性 | Human | ||||
MW (kDa) | 70kDa | ||||
抗体类型 | |||||
储存液配方 | 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. | ||||
储存条件 (自收到货起) |
Store at –20°C. |
WB
Validated by Selleck
IHC
Validated by Selleck