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特异性 | CDC42EP1 Rabbit Recombinant mAb detects endogenous level of total CDC42EP1. |
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背景 | The Rho GTPase family member Cdc42 regulates a diverse range of cellular functions including cytokinesis, cytoskeletal remodelling and cell polarity. Like other Rho family members, Cdc42 cycles between two tightly regulated conformational states, a GTP-bound active state and a GDP-bound inactive state. Activated Cdc42 exerts its functions by interacting with downstream effectors containing a Cdc42/Rac interactive binding (CRIB) motif. Several Cdc42 effector proteins, including kinases and scaffolds, have been well characterised. Cdc42 effector protein 1 (CDC42EP1) has been shown to interact with atypical PKC in mouse differentiating trophectoderm cells leading to increase cell motility, playing a role in regulating the migration and sorting of trophectoderm cells during embryogenesis. |
抗体应用 | WB,ELISA,ELISA | ||
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稀释比例 |
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反应性 | Human | ||
MW (kDa) | 60kDa | ||
抗体类型 | Rabbit | ||
储存液配方 | 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. | ||
储存条件 (自收到货起) |
Store at –20°C. |
WB
Validated by Selleck