CDC45 Rabbit Recombinant mAb

目录号：A5685

生物描述

特异性	CDC45 Rabbit Recombinant mAb detects endogenous level of total CDC45.
背景	Cdc45 is an essential protein conserved in all eukaryotes and is involved both in the initiation of DNA replication and the progression of the replication fork. With GINS, Cdc45 is an essential cofactor of the Mcm2–7 replicative helicase complex. Human Cdc45 protein is able to bind single-stranded, but not double-stranded DNA. As many other DNA replication factors, Cdc45 is more abundant in proliferating cells, whereas it is almost absent from long term quiescent, terminally differentiated, and senescent cells.

特异性

CDC45 Rabbit Recombinant mAb detects endogenous level of total CDC45.

背景

Cdc45 is an essential protein conserved in all eukaryotes and is involved both in the initiation of DNA replication and the progression of the replication fork. With GINS, Cdc45 is an essential cofactor of the Mcm2–7 replicative helicase complex. Human Cdc45 protein is able to bind single-stranded, but not double-stranded DNA. As many other DNA replication factors, Cdc45 is more abundant in proliferating cells, whereas it is almost absent from long term quiescent, terminally differentiated, and senescent cells.

使用信息

抗体应用

WB ,ELISA,ELISA

稀释比例

1:1000

反应性

Human Mouse Rat

MW (kDa)

65kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

[1] Krastanova I, et al. J Biol Chem. 2012, 287(6):4121-8.
[2] Broderick R, et al. Biochem Soc Trans. 2009, 37(Pt 4):926-30.

Application Data

Validated by Selleck