Cdk4 Rabbit Recombinant mAb

生物描述

特异性

Cdk4 Rabbit Recombinant mAb detects endogenous level of total CDK4.

背景

Cyclin-dependent kinase 4 (CDK4) is a member of the Ser/Thr protein kinase family and a master integrator that couples mitogenic and antimitogenic extracellular signals with the cell cycle. The six D-type cyclin-CDK4/6 complexes phosphorylate and inactivate the cell cycle/tumor suppressor proteins of the pRb family. CDK4/6 can also phosphorylate other substrates. CDK4 is demonstrated to phosphorylate and inactivate Smad3. Direct phosphorylations by CDK4 of the nucleolar transcription factor upstream binding factor (UBF), the replication licensing factor Cdt1, the bone-specific transcription factor Runx2, and possibly TSC2 have been reported. CDK4 activity is deregulated in many human tumors. It is crucial for various oncogenic transformation processes.

使用信息

抗体应用	WB, IF,ELISA,ELISA
稀释比例	WB IF 1:1000 1:50
反应性	Human Mouse Rat
MW (kDa)	34kDa
抗体类型	Rabbit
储存液配方	10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
储存条件 (自收到货起)	Store at –20°C.

文献参考

[1] Laurence Bockstaele, et al. Cell Div. 2006, 1: 25.

Application Data

WB

IF