Cediranib Maleate

目录号：S5242 批次号：S524201

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化学数据

化学结构式 别名 AZD2171 maleate 储存条件
(自收到货起)		 3年 -20°C 粉状
化学式

C25H27FN4O3.C4H4O4
分子量 566.58 CAS号 857036-77-2
Solubility (25°C)* 体外 DMSO 100 mg/mL (176.49 mM)
Water Insoluble
Ethanol Insoluble
体内（现配现用）
澄清溶液
5%DMSO Corn oil
5mg/ml (8.82mM) 以 1 mL 工作液为例，取50μL100mg/ml的澄清DMSO储备液加到950μL玉米油中，混合均匀。工作液请现配现用！
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

生物活性

产品描述 Cediranib Maleate (AZD2171) is the maleate salt of Cediranib, which is a potent inhibitor of VEGFR with IC50 of <1 nM and also inhibits Flt1/4 with IC50 of 5 nM/≤3 nM.
靶点
VEGFR2/KDR [2]
(HUVECs)		 c-Kit [2]
(HUVECs)		 c-Kit [2]
(HUVECs)		 VEGFR3/FLT4 [2]
(HUVECs)		 VEGFR1/FLT1 [2]
(HUVECs)		 View More
0.5 nM 2 nM 2 nM <=3 nM 5 nM

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

Cediranib Maleate在文献中得到引用

Combined inhibition of HER2 and VEGFR synergistically improves therapeutic efficacy via PI3K-AKT pathway in advanced ovarian cancer [ J Exp Clin Cancer Res, 2024, 43(1):56] PubMed: 38403634
The multi-kinase inhibitor afatinib serves as a novel candidate for the treatment of human uveal melanoma [ Cell Oncol (Dordr), 2022, 45(4):601-619] PubMed: 35781872
Immune Mechanisms of Resistance to Cediranib in Ovarian Cancer [ Mol Cancer Ther, 2022, 21(6):1030-1043] PubMed: 35313341
Preclinical Evaluation of Ixabepilone in Combination with VEGF Receptor and PARP Inhibitors in Taxane-Sensitive and Taxane-Resistant MDA-MB-231 Breast Cancer Cells [ J Pharm Sci, 2022, 111(8):2180-2190] PubMed: 35700798
Vitamin D Enhances Anticancer Properties of Cediranib, a VEGFR Inhibitor, by Modulation of VEGFR2 Expression in Melanoma Cells [ Front Oncol, 2021, 11:763895] PubMed: 35004285
Combined VEGFR and MAPK pathway inhibition in angiosarcoma [ Sci Rep, 2021, 11(1):9362] PubMed: 33931674
Advantages of Tyrosine Kinase Anti-Angiogenic Cediranib over Bevacizumab: Cell Cycle Abrogation and Synergy with Chemotherapy [ Pharmaceuticals (Basel), 2021, 14(7)682] PubMed: 34358108
Extension of the Mechanistic Tissue Distribution Model of Rodgers and Rowland by Systematic Incorporation of Lysosomal Trapping: Impact on Unbound Partition Coefficient and Volume of Distribution Predictions in the Rat [ Drug Metab Dispos, 2021, 49(1):53-61] PubMed: 33148688
Downregulation of long non-protein coding RNA MVIH impairs glioblastoma cell proliferation and invasion through a miR-302a-dependent mechanism [ Hum Mol Genet, 2021, ddab009] PubMed: 33438023
Comprehensive pharmacogenomic characterization of gastric cancer. [ Genome Med, 2020, 18;12(1):17] PubMed: 32070411

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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