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别名 | NSC-187208, CHQ, CQ | 储存条件 (自收到货起) |
3年 -20°C 粉状 | |
化学式 | C18H26ClN3 |
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分子量 | 319.87 | CAS号 | 54-05-7 | |
Solubility (25°C)* | 体外 | DMSO | 64 mg/mL (200.08 mM) | |
Ethanol | 64 mg/mL (200.08 mM) | |||
Water | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
产品描述 | Chloroquine (NSC-187208, CHQ, CQ)是抗疟药和自噬及溶酶体 autophagy/lysosome 的抑制剂。Chloroquine 还可抑制 Toll-like receptor-9 (TLR9) 蛋白的表达。Chloroquine 是非常有效的抗SARS-CoV-2 (COVID-19)侵染剂,在Vero E6细胞中的EC50值为1.13 μM。Chloroquine 也具有抗HIV-1活性。 | ||||||||||
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靶点 |
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Engineered a dual-targeting HA-TPP/A nanoparticle for combination therapy against KRAS-TP53 co-mutation in gastrointestinal cancers [ Bioact Mater, 2024, 32:277-291] | PubMed: 37876556 |
Dysregulated CREB3 cleavage at the nuclear membrane induces karyoptosis-mediated cell death [ Exp Mol Med, 2024, 56(3):686-699] | PubMed: 38480902 |
Fut2 Deficiency Promotes Intestinal Stem Cell Aging by Damaging Mitochondrial Functions via Down-Regulating α1,2-Fucosylation of Asah2 and Npc1 [ Research (Wash D C), 2024, 7:0343] | PubMed: 38550777 |
Sonic hedgehog restrains the ubiquitin-dependent degradation of SP1 to inhibit neuronal/glial senescence associated phenotypes in chemotherapy-induced peripheral neuropathy via the TRIM25-CXCL13 axis [ J Adv Res, 2024, S2090-1232(24)00106-1] | PubMed: 38479571 |
Inhibiting autophagy enhanced mitotic catastrophe-mediated anticancer immune responses by regulating the cGAS-STING pathway [ Cancer Lett, 2024, 586:216695] | PubMed: 38325769 |
Pinacidil ameliorates cardiac microvascular ischemia-reperfusion injury by inhibiting chaperone-mediated autophagy of calreticulin [ Basic Res Cardiol, 2024, 119(1):113-131] | PubMed: 38168863 |
PLEKHM2 deficiency induces impaired mitochondrial clearance and elevated ROS levels in human iPSC-derived cardiomyocytes [ Cell Death Discov, 2024, 10(1):142] | PubMed: 38490981 |
ULK2 Is a Key Pro-Autophagy Protein That Contributes to the High Chemoresistance and Disease Relapse in FLT3-Mutated Acute Myeloid Leukemia [ Int J Mol Sci, 2024, 25(1)646] | PubMed: 38203816 |
Migrasomal autophagosomes relieve endoplasmic reticulum stress in glioblastoma cells [ BMC Biol, 2024, 22(1):23] | PubMed: 38287397 |
Disruption of Autophagic Flux and Treatment with the PDPK1 Inhibitor GSK2334470 Synergistically Inhibit Renal Cell Carcinoma Pathogenesis [ J Cancer, 2024, 15(5):1429-1441] | PubMed: 38356720 |
特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品,在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同,大多数建议储存在-20°C,抑制剂属于化学试剂,可在常温下运输储存两周左右。即使如此,我们保证产品的出货量将保持产品质量的条件下,一般都会放入冰袋。望阁下收到产品后,请按照产品数据表建议适当存储。
如果需要长期保存,请于零下二十度低温保存。禁止用于人体及治疗!
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