CITED2 Rabbit Recombinant mAb Datasheet

生物描述

特异性	CITED2 Rabbit Recombinant mAb detects endogenous level of total CITED2.
背景	Glu/Asp-rich carboxy-terminal domain 2 (CITED2) is a cAMP-responsive element-binding protein (CBP)/p300 interacting transcriptional modulator and a proposed negative regulator for hypoxia-inducible factor (HIF)-1α through its competitive binding with HIF-1α to CBP/p300. CITED2 responds to TGF-α induction and TGF-β suppression to orchestrate cellular proliferation and quiescence, respectively. TGF-α induction and TGF-β suppression to orchestrate cellular proliferation and quiescence, respectively. CITED2 recruited p300 to promote MYC-p300-mediated transactivation of E2F3, leading to increased G1/S cell cycle progression. Moreover, CITED2 inhibited cellular quiescence by enhancing MYC-mediated suppression of p21(CIP1). CITED2 interacted with histone deacetylase 1 (HDAC1) and potentiated MYC-HDAC1 complex formation. Thus, CITED2 functions as a molecular switch of TGF-α and TGF-β-induced growth control.

特异性

CITED2 Rabbit Recombinant mAb detects endogenous level of total CITED2.

背景

Glu/Asp-rich carboxy-terminal domain 2 (CITED2) is a cAMP-responsive element-binding protein (CBP)/p300 interacting transcriptional modulator and a proposed negative regulator for hypoxia-inducible factor (HIF)-1α through its competitive binding with HIF-1α to CBP/p300. CITED2 responds to TGF-α induction and TGF-β suppression to orchestrate cellular proliferation and quiescence, respectively. TGF-α induction and TGF-β suppression to orchestrate cellular proliferation and quiescence, respectively. CITED2 recruited p300 to promote MYC-p300-mediated transactivation of E2F3, leading to increased G1/S cell cycle progression. Moreover, CITED2 inhibited cellular quiescence by enhancing MYC-mediated suppression of p21(CIP1). CITED2 interacted with histone deacetylase 1 (HDAC1) and potentiated MYC-HDAC1 complex formation. Thus, CITED2 functions as a molecular switch of TGF-α and TGF-β-induced growth control.

使用信息

抗体应用

WB ,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human Mouse

MW (kDa)

28kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

Application Data

WB

Validated by Selleck