Collagen VI Rabbit Recombinant mAb Datasheet

生物描述

特异性	Collagen VI Rabbit Recombinant mAb detects endogenous level of total Collagen VI.
背景	Collagen VI (ColVI) is an unusual member of the collagen family. ColVI exerts different roles in the tissues where it is expressed, spanning from mechanical roles, which are typical of collagen components of the ECM, to more specific cytoprotective functions; these include inhibition of apoptosis and oxidative damage, the promotion of tumor growth and progression, the regulation of cell differentiation and of the autophagic machinery, and maintenance of cell stemness. ColVI comprises the α1(VI), α2(VI) and α3(VI) chains, which assemble into a triple-helix monomer in a 1:1:1 stoichiometric ratio. ColVI is able to bind to different components of the ECM, thus bridging cells to the surrounding connective tissue and organizing the three-dimensional tissue architecture of skeletal muscles, tendons, bone and cartilage. ColVI also interacts with several membrane receptors that are involved in intracellular signaling pathways.

特异性

Collagen VI Rabbit Recombinant mAb detects endogenous level of total Collagen VI.

背景

Collagen VI (ColVI) is an unusual member of the collagen family. ColVI exerts different roles in the tissues where it is expressed, spanning from mechanical roles, which are typical of collagen components of the ECM, to more specific cytoprotective functions; these include inhibition of apoptosis and oxidative damage, the promotion of tumor growth and progression, the regulation of cell differentiation and of the autophagic machinery, and maintenance of cell stemness. ColVI comprises the α1(VI), α2(VI) and α3(VI) chains, which assemble into a triple-helix monomer in a 1:1:1 stoichiometric ratio. ColVI is able to bind to different components of the ECM, thus bridging cells to the surrounding connective tissue and organizing the three-dimensional tissue architecture of skeletal muscles, tendons, bone and cartilage. ColVI also interacts with several membrane receptors that are involved in intracellular signaling pathways.

使用信息

抗体应用

WB ,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human Mouse Rat

MW (kDa)

147kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

[1] Matilde Cescon, et al. J Cell Sci. 2015, 128: 3525-3531.

Application Data

WB

Validated by Selleck