CY-09

目录号:S5774 批次号:S577402

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化学数据

化学结构式 别名 N/A 储存条件
(自收到货起)
3年 -20°C 粉状
化学式

C19H12F3NO3S2

分子量 423.43 CAS号 1073612-91-5
Solubility (25°C)* 体外 DMSO 85 mg/mL (200.74 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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生物活性

产品描述 CY-09是一种特异的NLRP3 inflammasome的抑制剂,直接靶向NLRP3。它对5种主要的cytochrome P450酶的IC50值分别为18.9, 8.18, >50, >50 和 26.0 µM。
靶点
NLRP3 inflammasome [1]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

CY-09在文献中得到引用

FXR controls duodenogastric reflux-induced gastric inflammation through negatively regulating ER stress-associated TNXIP/NLPR3 inflammasome [ iScience, 2024, 27(3):109118] PubMed: 38439955
Inhibiting NLRP3 Inflammasome Activation by CY-09 Helps to Restore Cerebral Glucose Metabolism in 3×Tg-AD Mice [ Antioxidants (Basel), 2023, 12(3)722] PubMed: 36978970
Autophagy-based unconventional secretion of HMGB1 in glioblastoma promotes chemosensitivity to temozolomide through macrophage M1-like polarization [ J Exp Clin Cancer Res, 2022, 41(1):74] PubMed: 35193644
PEG2-Induced Pyroptosis Regulates the Expression of HMGB1 and Promotes hEM15A Migration in Endometriosis [ Int J Mol Sci, 2022, 23(19)11707] PubMed: 36233009
MiR-624-5p enhances NLRP3 augmented gemcitabine resistance via EMT/IL-1β/Wnt/β-catenin signaling pathway in ovarian cancer [ J Reprod Immunol, 2022, 150:103488] PubMed: 35124344
CY-09 attenuates the progression of osteoarthritis via inhibiting NLRP3 inflammasome-mediated pyroptosis [ Biochem Biophys Res Commun, 2021, 553:119-125] PubMed: 33765556
Low-density lipoprotein receptor (LDLR) regulates NLRP3-mediated neuronal pyroptosis following cerebral ischemia/reperfusion injury [ J Neuroinflammation, 2020, 17(1):330] PubMed: 33153475
Activation of the Nlrp3 Inflammasome Contributes to Shiga Toxin-Induced Hemolytic Uremic Syndrome in a Mouse Model [ Front Immunol, 2020, 11:619096] PubMed: 33552083
TREM-1 Exacerbates Neuroinflammatory Injury via NLRP3 Inflammasome-Mediated Pyroptosis in Experimental Subarachnoid Hemorrhage [ Transl Stroke Res, 2020, 10.1007/s12975-020-00840-x] PubMed: 32862402
NLRP3 Augmented Resistance to Gemcitabine in Triple-Negative Breast Cancer cells(TNBCC) via EMT/IL-1β/Wnt/β-catenin Signaling Pathway [ Biosci Rep, 2020, BSR20200730] PubMed: 32578856

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品,在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同,大多数建议储存在-20°C,抑制剂属于化学试剂,可在常温下运输储存两周左右。即使如此,我们保证产品的出货量将保持产品质量的条件下,一般都会放入冰袋。望阁下收到产品后,请按照产品数据表建议适当存储。

如果需要长期保存,请于零下二十度低温保存。禁止用于人体及治疗!

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