Cycloheximide

目录号：S7418 批次号：S741804

化学数据

	别名	NSC-185, Actidione, Naramycin A, CHX, FT 3422-2, NM-MCD 80	储存条件 (自收到货起)	3年 -20°C(避光) 粉状
	化学式	C₁₅H₂₃NO₄
	分子量	281.35	CAS号	66-81-9
Solubility (25°C)*	体外	DMSO	56 mg/mL (199.04 mM)
		Ethanol	56 mg/mL (199.04 mM)
		Water	15 mg/mL (53.31 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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生物活性

产品描述	Cycloheximide (NSC-185, Actidione, Naramycin A, CHX, FT 3422-2, NM-MCD 80)，一种抗真菌抗生素，是一种真核生物蛋白质合成（protein synthesis）抑制剂，对体内蛋白质合（protein synthesis）和 RNA 合成（RNA synthesis）的 IC50 分别为 532.5 nM 和 2880 nM。Cycloheximide抑制铁死亡并抑制自噬。在溶液中不稳定，请现配现用！此产品为危化品（急性毒性/易燃/皮肤腐蚀），请在穿戴防护面罩、防护手套和防护服后使用。

参考文献

[4] Santos DA, et al. Nucleic Acids Res. 2019;47(10):4974-4985.

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Cycloheximide在文献中得到引用

Engineered a dual-targeting HA-TPP/A nanoparticle for combination therapy against KRAS-TP53 co-mutation in gastrointestinal cancers [ Bioact Mater, 2024, 32:277-291]	PubMed: 37876556
EFHD2 suppresses intestinal inflammation by blocking intestinal epithelial cell TNFR1 internalization and cell death [ Nat Commun, 2024, 15(1):1282]	PubMed: 38346956
Activation of hepatic adenosine A1 receptor ameliorates MASH via inhibiting SREBPs maturation [ Cell Rep Med, 2024, 5(3):101477]	PubMed: 38508143
Elevated expression of WSB2 degrades p53 and activates the IGFBP3-AKT-mTOR-dependent pathway to drive hepatocellular carcinoma [ Exp Mol Med, 2024, 56(1):177-191]	PubMed: 38177295
Heterogeneous ferroptosis susceptibility of macrophages caused by focal iron overload exacerbates rheumatoid arthritis [ Redox Biol, 2024, 69:103008]	PubMed: 38142586
5-HT7R enhances neuroimmune resilience and alleviates meningitis by promoting CCR5 ubiquitination [ J Adv Res, 2024, S2090-1232(24)00079-1]	PubMed: 38432392
Diallyl disulfide induces DNA damage and growth inhibition in colorectal cancer cells by promoting POU2F1 ubiquitination [ Int J Biol Sci, 2024, 20(4):1125-1141]	PubMed: 38385081
Hsa_circ_0007990 promotes breast cancer growth via inhibiting YBX1 protein degradation to activate E2F1 transcription [ Cell Death Dis, 2024, 15(2):153]	PubMed: 38378679
Musashi-2 potentiates colorectal cancer immune infiltration by regulating the post-translational modifications of HMGB1 to promote DCs maturation and migration [ Cell Commun Signal, 2024, 22(1):117]	PubMed: 38347600
BOP1 contributes to the activation of autophagy in polycystic ovary syndrome via nucleolar stress response [ Cell Mol Life Sci, 2024, 81(1):101]	PubMed: 38409361

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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