全国免费电话:400-668-6834 -- 仅限中国地区 -- |
在线订购:QQ: 4006686834 电话订购:021-68591985 邮件订购:info@selleck.cn 我们也提供销售人员上门服务 |
技术支持电话:400-168-6834 我们将于一个工作日与您联系 |
目录号:A5895
特异性 | Cyclophilin A Rabbit Recombinant mAb detects endogenous levels of total Cyclophilin A. |
---|---|
背景 | Cyclophilin A (CyPA) is a ubiquitously distributed protein belonging to the immunophilin family. CyPA has peptidyl prolyl cis-trans isomerase (PPIase) activity, which regulates protein folding and trafficking. Cyclophilins are present in all cellular compartments, involved in processes including protein trafficking and maturation, receptor complex stabilization, apoptosis, receptor signaling, RNA processing, muscle differentiation, detoxification of reactive oxygen species (ROS), immune response, spliceosome assembly, miRNA activity and RISC assembly. Human CyPs consist of 16 family members that are structurally distinct. Among them, the most abundant member is CyPA, which makes up ∼0.1–0.6% of the total cytosolic proteins. CyPA is present intracellularly and can also be secreted from cells in response to inflammatory stimuli such as hypoxia, infection, and oxidative stress. The secreted form of CyPA may mediate intercellular communication acting as an autocrine/paracrine factor. Extracellular CyPA stimulates pro-inflammatory signals in endothelial cells (EC) and vascular smooth muscle cells (VSMC), being an nonmitogenic survival-enhancing autocrine factor that contributes to mouse embryonic stem cell growth, and has a potent chemotactic effect on leukocytes, monocytes, and lymphocytes. |
抗体应用 | WB, IHC,ELISA,ELISA | ||||
---|---|---|---|---|---|
稀释比例 |
|
||||
反应性 | Human Mouse Rat | ||||
MW (kDa) | 18kDa | ||||
抗体类型 | |||||
储存液配方 | 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. | ||||
储存条件 (自收到货起) |
Store at –20°C. |
|
WB
Validated by Selleck
IHC
Validated by Selleck