Cytokeratin 5 Rabbit Recombinant mAb

生物描述

特异性

Cytokeratin 5 Rabbit Recombinant mAb detects endogenous level of total Cytokeratin 5.

背景

Cytokeratins, keratin proteins found in the intracytoplasmic cytoskeleton of epithelial tissue, are an important component of intermediate filaments that help cells resist mechanical stress. Keratin 5 (and K14) are expressed primarily in basal keratinocytes in the epidermis, specifically in the stratified epithelium lining the skin and digestive tract. It dimerizes with keratin 14 and forms the intermediate filaments (IF) that make up the cytoskeleton of basal epithelial cells and is involved in several diseases including epidermolysis bullosa simplex and breast and lung cancers.

使用信息

抗体应用	WB, IHC, IF,ELISA,ELISA
稀释比例	WB IHC IF 1:1000 1:50 1:50
反应性	Human
MW (kDa)	62kDa
抗体类型	Rabbit
储存液配方	10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
储存条件 (自收到货起)	Store at –20°C.

文献参考

[1] Herrmann H, et al. Nat Rev Mol Cell Biol. 2007, 8(7):562-73. [2] Atkinson SD, et al. J Invest Dermatol. 2011, 131(10):2079-86.

Application Data

WB

IHC

IF