Dabrafenib Mesylate

目录号：S5069 批次号：S506903

化学数据

	别名	GSK2118436 Mesylate	储存条件 (自收到货起)	3年 -20°C 粉状
	化学式	C₂₃H₂₀F₃N₅O₂S₂.CH₄O₃S
	分子量	615.67	CAS号	1195768-06-9
Solubility (25°C)*	体外	DMSO	100 mg/mL (162.42 mM)
		Water	Insoluble
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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生物活性

产品描述

Dabrafenib Mesylate (GSK2118436) is the mesylate salt form of dabrafenib, an orally bioavailable inhibitor of B-raf (BRAF) protein with IC50s of 0.7 nM, 5.2 nM and 6.3 nM for B-Raf (V600E), B-Raf (WT) and C-Raf, respectively.

靶点

B-Raf (V600E) ^[1] (Cell-free assay)	B-Raf ^[1] (Cell-free assay)	C-Raf ^[1] (Cell-free assay)
0.7 nM	5.2 nM	6.3 nM

参考文献

Dabrafenib Mesylate在文献中得到引用

SB202190 Predicts BRAF-Activating Mutations in Primary Colorectal Cancer Organoids via Erk1-2 Modulation [ Cells, 2023, 12(4)664]	PubMed: 36831331
A modified fluctuation-test framework characterizes the population dynamics and mutation rate of colorectal cancer persister cells [ Nat Genet, 2022, 54(7):976-984]	PubMed: 35817983
Adaptive translational reprogramming of metabolism limits the response to targeted therapy in BRAFV600 melanoma [ Nat Commun, 2022, 13(1):1100]	PubMed: 35232962
Targeting SOX10-deficient cells to reduce the dormant-invasive phenotype state in melanoma [ Nat Commun, 2022, 13(1):1381]	PubMed: 35296667
Candidate therapeutic agents in a newly established triple wild-type mucosal melanoma cell line [ Cancer Commun (Lond), 2022, 42(7):627-647]	PubMed: 35666052
MCU controls melanoma progression through a redox-controlled phenotype switch [ EMBO Rep, 2022, 23(11):e54746]	PubMed: 36156348
Establishment and large-scale validation of a three-dimensional tumor model on an array chip for anticancer drug evaluation [ Front Pharmacol, 2022, 13:1032975]	PubMed: 36313330
Effects of dabrafenib and erlotinib combination treatment on anaplastic thyroid carcinoma [ Endocr Relat Cancer, 2022, 29(6):307-319]	PubMed: 35343921
SERPINB8 and furin regulate ITGAX expression and affect the proliferation and invasion of melanoma cells [ Exp Dermatol, 2022, 10.1111/exd.14677]	PubMed: 36134483
B-Raf inhibitor vemurafenib counteracts sulfur mustard-induced epidermal impairment through MAPK/ERK signaling [ Drug Chem Toxicol, 2022, 1-10]	PubMed: 34986718

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如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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