全国免费电话:400-668-6834 -- 仅限中国地区 -- |
在线订购:QQ: 4006686834 电话订购:021-68591985 邮件订购:info@selleck.cn 我们也提供销售人员上门服务 |
技术支持电话:400-168-6834 我们将于一个工作日与您联系 |
别名 | GSK2118436 Mesylate | 储存条件 (自收到货起) |
3年 -20°C 粉状 | |
化学式 | C23H20F3N5O2S2.CH4O3S |
|||
分子量 | 615.67 | CAS号 | 1195768-06-9 | |
Solubility (25°C)* | 体外 | DMSO | 100 mg/mL (162.42 mM) | |
Water | Insoluble | |||
Ethanol | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
产品描述 | Dabrafenib Mesylate (GSK2118436) is the mesylate salt form of dabrafenib, an orally bioavailable inhibitor of B-raf (BRAF) protein with IC50s of 0.7 nM, 5.2 nM and 6.3 nM for B-Raf (V600E), B-Raf (WT) and C-Raf, respectively. | ||||||
---|---|---|---|---|---|---|---|
靶点 |
|
|
SB202190 Predicts BRAF-Activating Mutations in Primary Colorectal Cancer Organoids via Erk1-2 Modulation [ Cells, 2023, 12(4)664] | PubMed: 36831331 |
A modified fluctuation-test framework characterizes the population dynamics and mutation rate of colorectal cancer persister cells [ Nat Genet, 2022, 54(7):976-984] | PubMed: 35817983 |
Adaptive translational reprogramming of metabolism limits the response to targeted therapy in BRAFV600 melanoma [ Nat Commun, 2022, 13(1):1100] | PubMed: 35232962 |
Targeting SOX10-deficient cells to reduce the dormant-invasive phenotype state in melanoma [ Nat Commun, 2022, 13(1):1381] | PubMed: 35296667 |
Candidate therapeutic agents in a newly established triple wild-type mucosal melanoma cell line [ Cancer Commun (Lond), 2022, 42(7):627-647] | PubMed: 35666052 |
MCU controls melanoma progression through a redox-controlled phenotype switch [ EMBO Rep, 2022, 23(11):e54746] | PubMed: 36156348 |
Establishment and large-scale validation of a three-dimensional tumor model on an array chip for anticancer drug evaluation [ Front Pharmacol, 2022, 13:1032975] | PubMed: 36313330 |
Effects of dabrafenib and erlotinib combination treatment on anaplastic thyroid carcinoma [ Endocr Relat Cancer, 2022, 29(6):307-319] | PubMed: 35343921 |
SERPINB8 and furin regulate ITGAX expression and affect the proliferation and invasion of melanoma cells [ Exp Dermatol, 2022, 10.1111/exd.14677] | PubMed: 36134483 |
B-Raf inhibitor vemurafenib counteracts sulfur mustard-induced epidermal impairment through MAPK/ERK signaling [ Drug Chem Toxicol, 2022, 1-10] | PubMed: 34986718 |
特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品,在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同,大多数建议储存在-20°C,抑制剂属于化学试剂,可在常温下运输储存两周左右。即使如此,我们保证产品的出货量将保持产品质量的条件下,一般都会放入冰袋。望阁下收到产品后,请按照产品数据表建议适当存储。
如果需要长期保存,请于零下二十度低温保存。禁止用于人体及治疗!
退换货政策
Selleck提供宽松的退换货承诺,努力为您营造最优的购物体验。每个订单Selleck只提供一次退换货服务,为了确保您的权益,请您仔细阅读以下内容:
1. 请在返还样品之前事先与我们取得联系,以确保产品是直接向我们或者当地代理商购买的;
2. 自收到货物起七天内,如因运输过程有问题或其他任何问题,您可以提出退换货要求;自收到货物起365天内,如因产品质量有问题,您可以提出退换货要求。
3. 请使用我们的快递账号进行退换货,您无需为此承担任何费用。
4. 如您已收到由Selleck开具的发票,则办理退货或订单金额发生变更的换货时,请将发票随商品一同返还给Selleck。请您妥善保管发票,如发票丢失,将无法办理退换货手续。
5. 对于合理的退换货要求,我们会在5个工作日内处理完成您的款项退还和新换货物的运输等,请耐心等待。