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目录号:A2020 批次号: A202001
Denosumab (anti-RANK ligand) (AMG-162) 是是一种全人源单克隆抗体,可选择性抑制灵长类动物 RANKL。Denosumab 可抑制 human RANKL (143–317) 刺激源自鼠 RAW 264.7 细胞的破骨细胞形成的能力,IC50 值为 1.64 nM。
CAS号 | 615258-40-7 |
---|---|
配制 | PBS Buffer, pH 7.4 |
推荐同型对照 | human IgG1 |
来源 | HEK293 |
储存条件 (自收到货起) |
Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles. |
除菌 | 0.2 μM filtered |
纯度 | 99.34% |
蛋白浓度 | 5 mg/ml |
内毒素 | <1 EU/mg |
Protocol for constructing in vivo and in vitro models integrating clinical and proteomic subtypes of chordoma [ STAR Protoc, 2025, 6(2):103719] | PubMed: 40156836 |
Clinical-proteomic classification and precision treatment strategy of chordoma [ Cell Rep Med, 2024, 5(10):101757] | PubMed: 39368483 |
TNFSF11/TNFRSF11A Axis Amplifies HDM-Induced Airway Remodeling by Strengthening TGFβ1/STAT3 Action [ Allergy Asthma Immunol Res, 2024, 16(4):399-421] | PubMed: 39155739 |
Rapamycin Inhibits Osteoclastogenesis and Prevents LPS-Induced Alveolar Bone Loss by Oxidative Stress Suppression [ ACS Omega, 2023, 8(23):20739-20754] | PubMed: 37323396 |
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