Dopamine Transporter Rabbit Recombinant mAb Datasheet

生物描述

特异性	Dopamine Transporter Rabbit Recombinant mAb detects endogenous level of Dopamine Transporter.
背景	The dopamine transporter (DAT) controls the spatial and temporal dynamics of dopamine (DA) neurotransmission by driving reuptake of extracellular transmitter into presynaptic neurons. DAT belongs to the SLC6 family of transporters that couple inward solute transport to downhill movement of Na+ and Cl−. DAT is regulated by multiple signaling systems, with PKC and ERK being two of the most well-characterized. DAT is the major mechanism responsible for clearance of extracellular dopamine and is regulated by post-translational modifications and binding partner interactions. Dysregulation of DAT is found in many dopaminergic diseases such as ADHD and bipolar disorder, Angelman syndrome and Parkinson's disease.

特异性

Dopamine Transporter Rabbit Recombinant mAb detects endogenous level of Dopamine Transporter.

背景

The dopamine transporter (DAT) controls the spatial and temporal dynamics of dopamine (DA) neurotransmission by driving reuptake of extracellular transmitter into presynaptic neurons. DAT belongs to the SLC6 family of transporters that couple inward solute transport to downhill movement of Na+ and Cl−. DAT is regulated by multiple signaling systems, with PKC and ERK being two of the most well-characterized. DAT is the major mechanism responsible for clearance of extracellular dopamine and is regulated by post-translational modifications and binding partner interactions. Dysregulation of DAT is found in many dopaminergic diseases such as ADHD and bipolar disorder, Angelman syndrome and Parkinson's disease.

使用信息

抗体应用

WB,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human

MW (kDa)

50kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

Application Data

WB

Validated by Selleck