Doxorubicin

目录号：E2516 批次号：E251602

化学数据

	别名	Adriamycin,Hydroxydaunorubicin	储存条件 (自收到货起)	3年 -20°C 粉状
	化学式	C₂₇H₂₉NO₁₁
	分子量	543.52	CAS号	23214-92-8
Solubility (25°C)*	体外	DMSO	100 mg/mL (183.98 mM)
		Water	100 mg/mL (183.98 mM)
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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生物活性

产品描述

Adriamycin (Doxorubicin, Hydroxydaunorubicin)是一种细胞毒性蒽环类抗生素，也是一种抗癌化疗药物，以IC50为2.67 μM抑制拓扑异构酶II（topoisomerase II，topo II），从而阻止DNA复制，诱导细胞凋亡，同时抑制人DNA拓扑异构酶I（Topoisomerase I，topo I），IC50为0.8 μM。

靶点

topoisomerase I ^[3] (in assay of DNA Topo I activity)	topoisomerase II ^[1] (in decatenation assay for topoisomerase II activity)
0.8 μM	2.67 μM

参考文献

Doxorubicin在文献中得到引用

Detection of senescence using machine learning algorithms based on nuclear features [ Nat Commun, 2024, 15(1):1041]	PubMed: 38310113
FTO ameliorates doxorubicin-induced cardiotoxicity by inhibiting ferroptosis via P53-P21/Nrf2 activation in a HuR-dependent m6A manner [ Redox Biol, 2024, 70:103067]	PubMed: 38316068
A versatile engineered extracellular vesicle platform simultaneously targeting and eliminating senescent stromal cells and tumor cells to promote tumor regression [ J Nanobiotechnology, 2024, 22(1):105]	PubMed: 38468249
Inhibiting autophagy enhanced mitotic catastrophe-mediated anticancer immune responses by regulating the cGAS-STING pathway [ Cancer Lett, 2024, 586:216695]	PubMed: 38325769
Induction of IFIT1/IFIT3 and inhibition of Bcl-2 orchestrate the treatment of myeloma and leukemia via pyroptosis [ Cancer Lett, 2024, 588:216797]	PubMed: 38462032
Synergistic antitumor activity between HER2 antibody-drug conjugate and chemotherapy for treating advanced colorectal cancer [ Cell Death Dis, 2024, 15(3):187]	PubMed: 38443386
Targeting the GPI transamidase subunit GPAA1 abrogates the CD24 immune checkpoint in ovarian cancer [ Cell Rep, 2024, 43(4):114041]	PubMed: 38573857
Overcoming doxorubicin resistance in triple-negative breast cancer using the class I-targeting HDAC inhibitor bocodepsin/OKI-179 to promote apoptosis [ Breast Cancer Res, 2024, 26(1):35]	PubMed: 38429789
Unveiling the Antiviral Properties of Panduratin A through SARS-CoV-2 Infection Modeling in Cardiomyocytes [ Int J Mol Sci, 2024, 24;25(3):1427.]	PubMed: 38338708
Targeting G9a/DNMT1 methyltransferase activity impedes IGF2-mediated survival in hepatoblastoma [ Hepatol Commun, 2024, 8(2)e0378]	PubMed: 38285887

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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