Ephrin B2 Rabbit Recombinant mAb

生物描述

特异性

Ephrin B2 Rabbit Recombinant mAb detects endogenous level of total Ephrin B2.

背景

Ephrins are membrane-tethered ligands for Eph family receptor tyrosine kinases (RTKs). Interactions between ephrins and Eph receptors present on contacting cells triggers bidirectional signaling events that have been shown to modulate the behavior of both cells. Eph-ephrin signaling regulates cell morphology and movements, primarily by stimulating downstream effectors that regulate actin cytoskeletal rearrangements. By driving the positioning of cells relative to their neighbors, the Eph-ephrin system directs key cell guidance events during embryonic development and in adult tissues. Ephrins are categorized into two subclasses: GPI-anchored ephrin-A ligands bind preferentially to EphA receptors, while ephrin-B ligands are transmembrane proteins that interact mainly with B-class Eph RTKs. Ephrin-B2 is involved in vascular remodeling in normal and tumor tissues. It is highly expressed in arteries. Its expression is controlled by VEGF and hypoxia and, accordingly, the ligand is upregulated at sites of physiological as well as pathological neovascularization in the adult. In the vasculature, ephrin-B2 is a marker of arterial endothelial cells

使用信息

抗体应用	WB, IF,ELISA,ELISA
稀释比例	WB IF 1:1000 1:50
反应性	Human Mouse Rat
MW (kDa)	50kDa
抗体类型	Rabbit
储存液配方	10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
储存条件 (自收到货起)	Store at –20°C.

文献参考

[1] Rüdiger Klein. Development 2012, 4105-4109. [2] Nakayama A, et al. Genes Dev. 2013, 27(23):2576-89. [3] Bochenek ML, et al. J Cell Sci. 2010, 123(Pt 8):1235-46.

Application Data

WB

IF