Estrogen Receptor beta Rabbit Recombinant mAb Datasheet

生物描述

特异性	Estrogen Receptor beta Rabbit Recombinant mAb detects endogenous level of total Estrogen Receptor beta.
背景	Estrogen regulates a plethora of functionally dissimilar processes in a broad range of tissues. The biological actions of estrogens are manifest only in cells expressing a specific high-affinity estrogen receptor (ER). The ER is in fact a ligand-dependent transcription factor. Two estrogen receptor types, named ERα and ERβ, are the major mediators of a variety of biolog-ical functions of estrogens. There are some common physiological roles for the two ERs, such as in the development and function of the ovaries, and in the protection of the cardiovascular system. The alpha subtype has a more prominent role on the mammary gland and uterus, as well as on the preservation of skeletal homeostasis and the regulation of metabolism. The beta subtype seems to have a more profound effect on the central nervous and immune systems, and it generally counteracts the ERα-promoted cell hyperproliferation in tissues such as breast and uterus.

特异性

Estrogen Receptor beta Rabbit Recombinant mAb detects endogenous level of total Estrogen Receptor beta.

背景

Estrogen regulates a plethora of functionally dissimilar processes in a broad range of tissues. The biological actions of estrogens are manifest only in cells expressing a specific high-affinity estrogen receptor (ER). The ER is in fact a ligand-dependent transcription factor. Two estrogen receptor types, named ERα and ERβ, are the major mediators of a variety of biolog-ical functions of estrogens. There are some common physiological roles for the two ERs, such as in the development and function of the ovaries, and in the protection of the cardiovascular system. The alpha subtype has a more prominent role on the mammary gland and uterus, as well as on the preservation of skeletal homeostasis and the regulation of metabolism. The beta subtype seems to have a more profound effect on the central nervous and immune systems, and it generally counteracts the ERα-promoted cell hyperproliferation in tissues such as breast and uterus.

使用信息

抗体应用

WB ,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human

MW (kDa)

59kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

Application Data

WB

Validated by Selleck