生物描述

特异性

Factor XIIIa Rabbit Recombinant mAb detects endogenous levels of total Factor XIIIa.

背景

Factor XIIIa is a blood coagulation prototransglutaminase, which becomes an activated component of the final stages of the clotting cascade as a result of the interaction with thrombin and Ca2+. FXIIIa plays a key role in fibrin stabilisation. In the plasma form, the enzyme is a heterotetramer composed of paired A and B subunits (A2B2). In the tissue or cellular form, the protein lacks the B subunits and is therefore structurally a homodimer of A subunits (A2). FXIII has a significant role in wound healing and the embryo implantation processes, which involve angiogenic pathways. In the case of wound healing FXIIIa is believed to be central to reducing vascular endothelial permeability during the repair process and is a potential new strategy in the treatment of increased vascular permeability particularly in diabetic wounds arising due to chronic venous insufficiency.

使用信息

抗体应用	WB, IHC,ELISA,ELISA
稀释比例	WB IHC 1:1000 1:50
反应性	Human
MW (kDa)	83kDa
抗体类型
储存液配方	10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
储存条件 (自收到货起)	Store at –20°C.

文献参考

[1] Catherine Stefanato, et al. Factor XIIIa Expression in Normal and Pathological Skin.

Application Data

WB

IHC