生物描述

特异性

FAK Rabbit Recombinant mAb detects endogenous levels of total FAK.

背景

Focal adhesion kinase (FAK) is a cytoplasmic protein tyrosine kinase that plays an essential role during embryonic development and in the pathogenesis of human disease, including cancer and cardiovascular disease. FAK is expressed in most tissues. Its expression is required in several tissues for normal development. In endothelial cells, FAK is required for embryonic angiogenesis and FAK expression is necessary for proper development of the heart. In the adult heart, FAK plays a role in the hypertrophic response; In neurons, FAK functions downstream of netrins to promote neurite outgrowth and axon guidance. FAK may also be involved in the development of human cancer. FAK responds to extracellular stimuli, including signals from the extracellular matrix (ECM), and regulates cellular processes such as proliferation and cell migration.

使用信息

抗体应用	WB, IHC,ELISA,ELISA
稀释比例	WB IHC 1:1000 1:50
反应性	Human Mouse Rat
MW (kDa)	119kDa
抗体类型
储存液配方	10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
储存条件 (自收到货起)	Store at –20°C.

文献参考

[1] Schaller MD. J Cell Sci. 2010, 123(Pt 7):1007-13. [2] Sulzmaier FJ, et al. Nat Rev Cancer. 2014, 14(9):598-610.

Application Data

WB

IHC