生物描述

特异性

FANCD2 Rabbit Recombinant mAb detects endogenous levels of total FANCD2.

背景

Fanconi anemia (FA) is a rare human genetic disease displaying various clinical symptoms such as severe bone marrow failure, an extremely high incidence of cancer, and many other congenital defects. Upon activation, FA group D2 protein (FANCD2) is monoubiquitinated at K561 and works in cooperation with other FA and non-FA proteins to repair DNA damage. FANCD2 can perform the signaling transduction role in ATM signaling. Specifically, the phosphorylation of FANCD2 at Ser222, initiated by ATM, contributes to arresting cells in the S phase of the cell cycle. In the early phases of the DNA damage response, FANCD2 plays a crucial role as a sensor as well as a messenger for the timely repair of damaged DNA.

使用信息

抗体应用	WB, IF,ELISA,ELISA
稀释比例	WB IF 1:1000 1:50
反应性	Human Mouse Rat
MW (kDa)	166kDa
抗体类型
储存液配方	10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
储存条件 (自收到货起)	Store at –20°C.

文献参考

[1] Manoj Nepal, et al. Int J Mol Sci. 2017, 18(8): 1804.

Application Data

WB

IF