FGF21 Rabbit Recombinant mAb Datasheet

生物描述

特异性	FGF21 Rabbit Recombinant mAb detects endogenous level of total FGF21.
背景	The fibroblast growth factor receptor (FGFR) family of receptor tyrosine kinases plays important roles in development and tissue repair through the initiation of multiple signaling cascades controlling proliferation, differentiation, migration, and survival. There are four FGF receptors (FGFR1-4). Signaling by FGFR is initiated upon ligand binding, when the FGFRs dimerize and autophosphorylate up to seven tyrosine residues in the intracellular catalytic domain of the receptor to activate downstream signaling cascades. FGFR1 has been shown to be associated with Pfeiffer syndrome.

特异性

FGF21 Rabbit Recombinant mAb detects endogenous level of total FGF21.

背景

The fibroblast growth factor receptor (FGFR) family of receptor tyrosine kinases plays important roles in development and tissue repair through the initiation of multiple signaling cascades controlling proliferation, differentiation, migration, and survival. There are four FGF receptors (FGFR1-4). Signaling by FGFR is initiated upon ligand binding, when the FGFRs dimerize and autophosphorylate up to seven tyrosine residues in the intracellular catalytic domain of the receptor to activate downstream signaling cascades. FGFR1 has been shown to be associated with Pfeiffer syndrome.

使用信息

抗体应用

WB ,ELISA,ELISA

稀释比例

WB

1:500

反应性

Human Mouse Rat

MW (kDa)

22kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

Application Data

WB

Validated by Selleck