MEK7 Rabbit Recombinant mAb Datasheet

生物描述

特异性	FOXO4 Rabbit Recombinant mAb detects endogenous level of total FOXO4.
背景	FoxO4 is a member of the forkhead box transcription factor O (FoxO) subfamily. FoxO proteins are involved in diverse biological processes. FoxO4 inhibits the transcriptional activity of NF-κB and its activity may be regulated at transcriptional level by inflammatory signals. Nuclear expression of FOXO4 results in the suppression of various responses to hypoxia, including decreased vascular endothelial growth factor, glucose transporter 1, and erythropoietin expression. FOXO4 down-regulates the HIF-1α protein levels, consistent with the lack of hypoxia responsiveness.

特异性

FOXO4 Rabbit Recombinant mAb detects endogenous level of total FOXO4.

背景

FoxO4 is a member of the forkhead box transcription factor O (FoxO) subfamily. FoxO proteins are involved in diverse biological processes. FoxO4 inhibits the transcriptional activity of NF-κB and its activity may be regulated at transcriptional level by inflammatory signals. Nuclear expression of FOXO4 results in the suppression of various responses to hypoxia, including decreased vascular endothelial growth factor, glucose transporter 1, and erythropoietin expression. FOXO4 down-regulates the HIF-1α protein levels, consistent with the lack of hypoxia responsiveness.

使用信息

抗体应用

WB ,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human Mouse Rat

MW (kDa)

65kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

Application Data

WB

Validated by Selleck