FUS/TLS Rabbit Recombinant mAb Datasheet

生物描述

特异性	FUS/TLS Rabbit Recombinant mAb detects endogenous level of total FUS/TLS.
背景	TLS/FUS (TLS) is a multifunctional protein implicated in a wide range of cellular processes, including transcription and mRNA processing, as well as in both cancer and neurological disease. TLS also associates with RNAP III-transcribed genes and represses their transcription both in vitro and in vivo. TLS has also been linked to splicing. It contains an RNP-type RNA-binding domain and associates directly with SR protein splicing factor. TLS was found associated with RNAP II and snRNPs in a transcription and splicing complex in vitro.

特异性

FUS/TLS Rabbit Recombinant mAb detects endogenous level of total FUS/TLS.

背景

TLS/FUS (TLS) is a multifunctional protein implicated in a wide range of cellular processes, including transcription and mRNA processing, as well as in both cancer and neurological disease. TLS also associates with RNAP III-transcribed genes and represses their transcription both in vitro and in vivo. TLS has also been linked to splicing. It contains an RNP-type RNA-binding domain and associates directly with SR protein splicing factor. TLS was found associated with RNAP II and snRNPs in a transcription and splicing complex in vitro.

使用信息

抗体应用

WB,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human Mouse Rat

MW (kDa)

70kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

[1] Tan AY, et al. Proc Natl Acad Sci U S A. 2012, 109(16):6030-5.

Application Data

WB

Validated by Selleck