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别名 | N/A | 储存条件 (自收到货起) |
3年 / -20°C / 粉状 1年 / -80°C / 溶于溶剂 |
化学式 | C25H16ClN7O3S |
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分子量 | 529.96 | CAS号 | 1380672-07-0 | |
Solubility (25°C)* | 体外 | DMSO | 100 mg/mL (188.69 mM) | |
Water | Insoluble | |||
Ethanol | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
产品描述 | G007-LK是一种有效的选择性tankyrase抑制剂,对TNKS1/2的IC50分别为46 nM 和 25 nM。 | ||||
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靶点 |
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, Bone, 2018, 106:156-166
PARP inhibitors suppress tumours via centrosome error-induced senescence independent of DNA damage response [ EBioMedicine, 2024, 103:105129] | PubMed: 38640836 |
Targeting ErbB and tankyrase1/2 prevent the emergence of drug-tolerant persister cells in ALK-positive lung cancer [ NPJ Precis Oncol, 2024, 8(1):264] | PubMed: 39551860 |
A genome-wide screen links peroxisome regulation with Wnt signaling through RNF146 and tankyrase [ bioRxiv, 2024, 2024.02.02.578667] | PubMed: 38352406 |
Integrated clinical and genomic analysis identifies driver events and molecular evolution of colitis-associated cancers [ Nat Commun, 2023, 14(1):110] | PubMed: 36611031 |
The Adenoviral E1B-55k Protein Present in HEK293 Cells Mediates Abnormal Accumulation of Key WNT Signaling Proteins in Large Cytoplasmic Aggregates [ Genes (Basel), 2021, 12(12)1920] | PubMed: 34946869 |
Somatic tissue engineering in mouse models reveals an actionable role for WNT pathway alterations in prostate cancer metastasis. [ Cancer Discov, 2020, 6 pii: CD-19-1242] | PubMed: 32376773 |
TDP-43 a Protein Central to Amyotrophic Lateral Sclerosis Is Destabilized by Tankyrase-1/2 [ J Cell Sci, 2020, 14;jcs245811] | PubMed: 32409565 |
Response of Breast Cancer Cells to PARP Inhibitors Is Independent of BRCA Status. [ J Clin Med, 2020, 30;9(4)] | PubMed: 32235451 |
Tankyrase promotes primary precursor miRNA processing to precursor miRNA. [ Biochem Biophys Res Commun, 2020, 522(4):945-951] | PubMed: 31806370 |
[ PLoS ONE, 2019, ] | PubMed: 31891587 |
特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品,在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同,大多数建议储存在-20°C,抑制剂属于化学试剂,可在常温下运输储存两周左右。即使如此,我们保证产品的出货量将保持产品质量的条件下,一般都会放入冰袋。望阁下收到产品后,请按照产品数据表建议适当存储。
如果需要长期保存,请于零下二十度低温保存。禁止用于人体及治疗!
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