GAD67 Rabbit Recombinant mAb Datasheet

生物描述

特异性	GAD67 Rabbit Recombinant mAb detects endogenous level of total GAD67.
背景	GAD67 is one of two major isoforms of GAD, an enzyme that converts glutamate to GABA. GAD67 exists as both homo- and heterodimers in both soluble and membrane-bound forms, primarily within the cell soma but also to a limited degree in terminals. In the adult, it is thought to be critical for the maintenance of intracellular GABA reserves for metabolic activity and other functions, rather than for vesicular release. GAD67, but not GAD65, protein levels can be influenced by intraneuronal GABA levels and this occurs without a change in the level of GAD67 mRNA.

特异性

GAD67 Rabbit Recombinant mAb detects endogenous level of total GAD67.

背景

GAD67 is one of two major isoforms of GAD, an enzyme that converts glutamate to GABA. GAD67 exists as both homo- and heterodimers in both soluble and membrane-bound forms, primarily within the cell soma but also to a limited degree in terminals. In the adult, it is thought to be critical for the maintenance of intracellular GABA reserves for metabolic activity and other functions, rather than for vesicular release. GAD67, but not GAD65, protein levels can be influenced by intraneuronal GABA levels and this occurs without a change in the level of GAD67 mRNA.

使用信息

抗体应用

WB, IHC,ELISA

稀释比例

WB	IHC
1:1000	1:50

反应性

Human Mouse Rat

MW (kDa)

67kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

[1] Straub RE, et al. Mol Psychiatry. 2007, 12(9):854-69.

Application Data

WB

Validated by Selleck

IHC

Validated by Selleck