Datasheet

生物描述

特异性	GARS Rabbit Recombinant mAb detects endogenous levels of total GARS.
背景	Glycyl-tRNA synthetase (GARS) is responsible for covalently linking glycine with corresponding tRNAs in an ATP-dependent reaction. Charged tRNAgly is then used in protein synthesis in the ribosome. GARS is thus ubiquitously expressed and absolutely necessary for protein translation in all cells. Like other mammalian aminoacyl-tRNA synthetases (aaRS), it is involved in functions beyond translation. GARS is indeed secreted by macrophages and acts as a cytokine with a distinct role against specific tumor cells. Moreover, GARS binds the Internal Ribosome Entry Site (IRES) located at the 5′-end of the poliovirus RNA genome and promotes its cap-independent translation initiation. In mammals, GARS expression may be regulated in response to many different stimuli.

特异性

GARS Rabbit Recombinant mAb detects endogenous levels of total GARS.

背景

Glycyl-tRNA synthetase (GARS) is responsible for covalently linking glycine with corresponding tRNAs in an ATP-dependent reaction. Charged tRNAgly is then used in protein synthesis in the ribosome. GARS is thus ubiquitously expressed and absolutely necessary for protein translation in all cells. Like other mammalian aminoacyl-tRNA synthetases (aaRS), it is involved in functions beyond translation. GARS is indeed secreted by macrophages and acts as a cytokine with a distinct role against specific tumor cells. Moreover, GARS binds the Internal Ribosome Entry Site (IRES) located at the 5′-end of the poliovirus RNA genome and promotes its cap-independent translation initiation. In mammals, GARS expression may be regulated in response to many different stimuli.

使用信息

抗体应用

wb,ELISA,ELISA

稀释比例

WB

1:500

反应性

Human Mouse Rat

MW (kDa)

75kDa

抗体类型

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

Application Data

WB

Validated by Selleck