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别名 | N/A | 储存条件 (自收到货起) |
3年 -20°C 粉状 | |
化学式 | C21H30N3NaO8S |
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分子量 | 507.53 | CAS号 | 1416992-39-6 | |
Solubility (25°C)* | 体外 | DMSO | 100 mg/mL (197.03 mM) | |
Water | 100 mg/mL (197.03 mM) | |||
Ethanol | 2 mg/mL (3.94 mM) | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
产品描述 | GC376 是一种 3CLpro (3C-like protease) 的抑制剂,对于PEDV 3CLpro的IC50值约为1.11 μM。GC376 对多种冠状病毒(包括SARS-CoV)的3CLpro有活性。 | ||
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靶点 |
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Enterovirus D68 3C protease antagonizes type I interferon signaling by cleaving signal transducer and activator of transcription 1 [ J Virol, 2024, 98(2):e0199423] | PubMed: 38240591 |
An RNA replicon system to investigate promising inhibitors of feline coronavirus [ J Virol, 2024, e0121623.] | PubMed: 38236006 |
A bat MERS-like coronavirus circulates in pangolins and utilizes human DPP4 and host proteases for cell entry [ Cell, 2023, 186(4):850-863.e16] | PubMed: 36803605 |
Insights into the mechanism of SARS-CoV-2 main protease autocatalytic maturation from model precursors [ Commun Biol, 2023, 10.1038/s42003-023-05469-8] | PubMed: 37957287 |
Stabilization of the Dimeric State of SARS-CoV-2 Main Protease by GC376 and Nirmatrelvir [ Int J Mol Sci, 2023, 24(7)6062] | PubMed: 37047038 |
Stabilization of the Dimeric State of SARS-CoV-2 Main Protease by GC376 and Nirmatrelvir [ Int. J. Mol. Sci, 2023, 10.3390/ijms24076062] | PubMed: None |
Enterovirus D68 Infection Induces TDP-43 Cleavage, Aggregation, and Neurotoxicity [ J Virol, 2023, 97(4):e0042523] | PubMed: 37039659 |
Lichen or Associated Micro-Organism Compounds Are Active against Human Coronaviruses [ Viruses, 2023, 15(9)1859] | PubMed: 37766264 |
Construction and characterization of two SARS-CoV-2 minigenome replicon systems [ J Med Virol, 2022, 10.1002/jmv.27650] | PubMed: 35137972 |
Modulation of the monomer-dimer equilibrium and catalytic activity of SARS-CoV-2 main protease by a transition-state analog inhibitor [ Commun Biol, 2022, 5(1):160] | PubMed: 35233052 |
特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品,在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同,大多数建议储存在-20°C,抑制剂属于化学试剂,可在常温下运输储存两周左右。即使如此,我们保证产品的出货量将保持产品质量的条件下,一般都会放入冰袋。望阁下收到产品后,请按照产品数据表建议适当存储。
如果需要长期保存,请于零下二十度低温保存。禁止用于人体及治疗!
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