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|   | 别名 | N/A | 储存条件 (自收到货起) | 3年 -20°C 粉状 | |||
| 化学式 | C21H30N3NaO8S | ||||||
| 分子量 | 507.53 | CAS号 | 1416992-39-6 | ||||
| Solubility (25°C)* | 体外 | DMSO | 100 mg/mL (197.03 mM) | ||||
| Water | 100 mg/mL (197.03 mM) | ||||||
| Ethanol | 2 mg/mL (3.94 mM) | ||||||
| 体内 (现配现用) | 
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| *  <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. | |||||||
| 产品描述 | GC376 是一种 3CLpro (3C-like protease) 的抑制剂,对于PEDV 3CLpro的IC50值约为1.11 μM。GC376 对多种冠状病毒(包括SARS-CoV)的3CLpro有活性。 | ||
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| Differential tropisms of old and new world hantaviruses influence virulence and developing host-directed antiviral candidates [ PLoS Pathog, 2025, 21(8):e1013401] | PubMed: 40857262 | 
| Characterization of an unusual SARS-CoV-2 main protease natural variant exhibiting resistance to nirmatrelvir and ensitrelvir [ Commun Biol, 2025, 8(1):1061] | PubMed: 40676153 | 
| Cullin 3-mediated ubiquitination restricts enterovirus D68 replication and is counteracted by viral protease 3C [ J Virol, 2025, 99(6):e0035425] | PubMed: 40396757 | 
| Development of a Biosafety Level 1 Cellular Assay for Identifying Small-Molecule Antivirals Targeting the Main Protease of SARS-CoV-2: Evaluation of Cellular Activity of GC376, Boceprevir, Carmofur, Ebselen, and Selenoneine [ Int J Mol Sci, 2024, 25(11)5767] | PubMed: 38891954 | 
| Enterovirus D68 3C protease antagonizes type I interferon signaling by cleaving signal transducer and activator of transcription 1 [ J Virol, 2024, 98(2):e0199423] | PubMed: 38240591 | 
| An RNA replicon system to investigate promising inhibitors of feline coronavirus [ J Virol, 2024, e0121623.] | PubMed: 38236006 | 
| An efficient trans complementation system for in vivo replication of defective poliovirus mutants [ J Virol, 2024, 98(7):e0052324] | PubMed: 38837378 | 
| Design of novel and highly selective SARS-CoV-2 main protease inhibitors [ Antimicrob Agents Chemother, 2024, 68(10):e0056224] | PubMed: 39225484 | 
| Characterization of alternate encounter assemblies of SARS-CoV-2 main protease [ J Biol Chem, 2024, S0021-9258(24)02176-8] | PubMed: 39128719 | 
| SARS-CoV-2 Mpro inhibitor identification using a cellular gain-of-signal assay for high-throughput screening [ SLAS Discov, 2024, S2472-5552(24)00043-1] | PubMed: 39173830 | 
特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品,在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同,大多数建议储存在-20°C,抑制剂属于化学试剂,可在常温下运输储存两周左右。即使如此,我们保证产品的出货量将保持产品质量的条件下,一般都会放入冰袋。望阁下收到产品后,请按照产品数据表建议适当存储。
如果需要长期保存,请于零下二十度低温保存。禁止用于人体及治疗!
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