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别名 | N/A | 储存条件 (自收到货起) |
3年 / -20°C / 粉状 1年 / -80°C / 溶于溶剂 |
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化学式 | C21H18ClFN6O2 |
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分子量 | 439.85 | CAS号 | 1453848-26-4 | |
Solubility (25°C)* | 体外 | DMSO | 88 mg/mL (200.06 mM) | |
Ethanol | 88 mg/mL (200.06 mM) | |||
Water | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
产品描述 | Ravoxertinib (GDC-0994)是一种有效的,可口服的, 具有选择性的 ERK1/2 抑制剂, 其IC50分别为1.1 nM和0.3 nM。 Phase 1。 | ||||
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体外研究 | GDC-0994有效抑制肿瘤细胞中磷酸-p90RSK。[1] |
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体内研究 | GDC-0994(口服)在体外癌症模型中引起显著的多重单剂量活性,包括KRAS突变型和 BRAF突变型人异种移植肿瘤的小鼠。[1] 在体内,GDC-0994 (口服)抑制ERK磷酸化和ERK介导的信号转导通路的激活,随后防止ERK依赖性肿瘤细胞增殖和存活。[2] |
数据来源于[Data independently produced by , , Blood, 2018, 131(18):2047-2059]
数据来源于[Data independently produced by , , Biochim Biophys Acta, 2015, 1852(12):2671-7]
数据来源于[Data independently produced by , , Biochem Biophys Res Commun, 2017, 486(4):1062-1068]
数据来源于[Data independently produced by , , Cell Immunol, 2017, 314:63-72]
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ERK1/2-Dependent Phosphorylation of GABAB1-S867/T872), Controlled by CaMKIIβ, Is Required for GABAB Receptor Degradation under Physiological and Pathological Conditions [ Int J Mol Sci, 2023, 24(17)13436] | PubMed: 37686242 |
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A Chemical Proteomics Approach to Discover Regulators of Innate Immune Signaling [ Viruses, 2023, 15(5)1112] | PubMed: 37243198 |
Synergism of Carbamoylated Erythropoietin and Insulin-like Growth Factor-1 in Immediate Early Gene Expression [ Life (Basel), 2023, 13(9)1826] | PubMed: 37763230 |
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如果需要长期保存,请于零下二十度低温保存。禁止用于人体及治疗!
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